Synergistic effect of SSRI/SNRI and mutual interaction on the development of social affiliation behavior through high sensitive period

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  • Nakamura Shun
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • 小柴 満美子
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology

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  • 共感性障害の脳内機構と治療的臨界期
  • キョウカンセイ ショウガイ ノ ノウナイ キコウ ト チリョウテキ リンカイキ

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Abstract

Social affiliation develops through sensory-motor interaction between social agents. We have established a new integrative behavior analysis method to quantitatively evaluate the social behavior and examined the development of social affiliation behavior in two animal models (domestic chick and common marmoset). We found that chick developed the affiliation behavior through a sensitive period and SSRI/SNRI was effective for the chick which did not experience social interaction in the period, but did after the period. This result suggests the possible contribution of our animal model to shed more light on the neural basis of social behavior deficit in developmental disorders and other psychiatric disorders.

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