Regulation of presenilin/gamma-secretase function ; towards intervention of Alzheimer disease in future
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- Tagami Shinji
- Department of Psychiatry, Osaka University Graduate School of Medicine
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- Okochi Masayasu
- Department of Psychiatry, Osaka University Graduate School of Medicine
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- Nishimura Masaki
- Shiga University of Medical Science
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- Funamoto Satoru
- Doshisha University
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- Tomita Taisuke
- Department of neuropathology and Neuroscience Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Takeda Masatoshi
- Department of Psychiatry, Osaka University Graduate School of Medicine
Bibliographic Information
- Other Title
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- アミロイドβ蛋白 42(Aβ42)を産生するプレセニリン・γセクレターゼに関する最新の知見
- アミロイドvタンパク 42(Av42)オ サンセイ スル プレセニリン ・gセクレターゼ ニ カンスル サイシン ノ チケン
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Abstract
In the symposium entitled “Regulation of presenilin/gamma-secretase function; towards intervention of Alzheimer disease in future” , four speakers presented new data about presenilin/gamma-secretase. Okochi and Tagami presented that toxic Aβ42 is directly cleaved into non-toxic toxic Aβ38 in living cells and analyzed the process in detail. Dr. Nishimura presented that gamma-secretase activity undergoes an age-related, non-genetic modulation through analysis of Aβ peptides in CSF of cynomolgus monkeys. Dr. Funamoto presented that gamma-secretase distinguishes the ectodomain length of substrates and that the ectodomain of C99 (the precursor of Aβ peptides) is a potent target for substrate-specific inhibition of both beta-and gamma-secretases. Dr. Tomita presented that gamma-Secretase activity is regulated by its subcellular localization, which might impact the enzymatic activity and synaptic function. Each speaker summarized their presentation below together with one figure. Okochi and Dr. Nishimura presided chair.
Journal
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- Japanese Journal of Biological Psychiatry
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Japanese Journal of Biological Psychiatry 25 (1), 11-17, 2014
Japanese Society of Biological Psychiatry
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Details 詳細情報について
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- CRID
- 1390282680389612544
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- NII Article ID
- 130005395516
- 40020058270
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- NII Book ID
- AA12468060
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- ISSN
- 21866465
- 21866619
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- NDL BIB ID
- 025444909
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed