Biomarkers and therapeutic targets of depressive disorder：A joint symposium of Max Planck Institute of Psychiatry and National Center of Neurology and Psychiatry, Japan

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  • Kunugi Hiroshi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry

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  • うつ病のバイオマーカーと治療標的分子：マックスプランク精神医学研究所と国立精神・神経医療研究センターのジョイントシンポジウム
  • ウツビョウ ノ バイオマーカー ト チリョウ ヒョウテキ ブンシ : マックスプランク セイシン イガク ケンキュウジョ ト コクリツ セイシン ・ シンケイ イリョウ ケンキュウ センター ノ ジョイントシンポジウム

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Abstract

This symposium was organized by the Max Planck Institute of Psychiatry (President: F. Holsboer) and the National Center of Neurology and Psychiatry (President: T. Higuchi) to present and discuss recent progress in research on biomarkers and therapeutic targets of depressive disorder. The first speaker, H. Kunugi, showed that dexamethasone/CRH test is a useful marker for subtyping depressive disorder and that two molecules (FKBP5 and ABCB1) play an important role in the HPA axis regulation and the pathogenesis of depressive disorder. The second speaker, M. Ising, presented compelling data on the role of FKBP5 and ABCB1 to predict response to antidepressants and demonstrated that gene expression in the peripheral blood and single nucleotide polymorphisms of these genes are useful biomarkers for personalized medicine in the treatment of depressive disorder. The third speaker, T. Numakawa, presented his cell biology research showing that long- term exposure to excessive glucocorticoid, the end product of the HPA axis, has a detrimental effect on brain- derived neurotrophic factor (BDNF) function in cultured cortical neurons. The last speaker, CW. Turck, presented a series of studies in mice using proteomics and metabolomics. His group found that molecules related to energy metabolism and oxidative stress were commonly altered in mice with high anxiety - like behavior and those mice treated with paroxetine. Overall, the symposium was very fruitful to provide recent knowledge on important progress and future directions of research on biomarkers and therapeutic targets of depressive disorder, which will facilitate the cooperative relationship between German and Japanese researchers.

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