Evaluation system of animal models to study cognitive function

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  • Kajii Yasushi
    Neuroscience Medical Franchise, Medical, Novartis Pharma K. K.

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  • 認知機能研究のための動物モデル評価系
  • ニンチ キノウ ケンキュウ ノ タメ ノ ドウブツ モデル ヒョウカケイ

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Abstract

To meet the needs in translational research of neuropsychiatric disorders, animal models should focus on a specific factor of dysfunction and their validity should be discussed in a multi-layer structure from molecules to observational phenotypes. Cognitive inflexibility is one of schizophrenia - characteristic cognitive capacities and Wisconsin Card Sorting Test is frequently used to obtain corresponding scores of extra-dimensional (ED) set shifting. Even in cases of rodents, ED set shifting task based on three categories of queues has been established and approaches to understand cognitive inflexibility in schizophrenia, as a multi-layer structure model of ED set shifting, are now available. In the course of dementia, deficit of paired association learning (PAL) is observed at its early stage and progresses. This specific cognitive capacity can be investigated in both human and rodents by a common experimental paradigm as schema - dependent learning of a map. Understanding schema - dependent PAL in a multi - layer structure model would be valuable to propose novel treatment strategies for dementia.

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