Muscle mechanoreflex mediates vasoconstriction in inactive limb in rats

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  • Endo Masako Y
    Department of Exercise Science and Physiology, School of Health Sciences, Prefectural University of Hiroshima
  • Hayashi Naoyuki
    School of Health and Sport Sciences, Osaka University
  • Koba Satoshi
    School of Health and Sport Sciences, Osaka University
  • Morizono Yuka
    Department of Exercise Science and Physiology, School of Health Sciences, Prefectural University of Hiroshima
  • Ueoka Hatsumi
    Department of Exercise Science and Physiology, School of Health Sciences, Prefectural University of Hiroshima
  • Fujihara Chizuko
    Department of Exercise Science and Physiology, School of Health Sciences, Prefectural University of Hiroshima
  • Fukuba Yoshiyuki
    Department of Exercise Science and Physiology, School of Health Sciences, Prefectural University of Hiroshima

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Abstract

We determined whether, stimulation of mechanosensitive receptors in active muscle (muscle mechanoreflex activation) induces vasoconstriction in the contralateral non-active muscles. In mid-collicular decerebrated rats (n = 9), we measured the blood flow of the left iliac artery when the right Achilles tendon was stretched by 300 g for 30 seconds (s) to stimulate mechanoreceptors in the triceps surae muscles. The stretch significantly increased the mean arterial pressure (MAP: +20 ± 3%, peak increase from baseline; mean ± SEM) and decreased the vascular conductance (VC) in the left iliac artery (–9 ± 1%, averaged over the stimulation period). After cutting the left sciatic nerve, the stretch did not significantly change the VC (+5 ± 1%), while it significantly increased MAP (+13 ± 3%, peak). In conclusion, the muscle mechanoreflex plays a role in mediating vasoconstriction in the contralateral limb via sympathetic activation.

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