Alpha-actinin isoform and skeletal muscle activity

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  • Ogura Yuji
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville
  • Kakigi Ryo
    Department of Physiology, School of Medicine, Juntendo University
  • Naito Hisashi
    Department of Exercise Physiology, Graduate School of Health and Sports Science, Juntendo University

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Alpha (α)-actinin is an actin-binding protein in mammalian cells. In skeletal muscles, α-actinin is located in the Z-line of sarcomeres, where it creates actin-actin crosslinks. We have recently reported that α-actinin adaptation occurs at the isoform level in rat skeletal muscle under different physiological conditions in an isoform-specific manner. Based on those results, this review briefly summarized the effects of changes in muscle activity on α-actinin expression.

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