Effect of low-osmolality contrast media(CM) on red blood cell filterability and morphology

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  • Ito Masayoshi
    The Third Department of Internal Medicine, Kyorin University

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Other Title
  • 赤血球の変形能と形態に及ぼす低浸透圧性ヨード造影剤の作用
  • 赤血球の変形能と形態に及ぼす低浸透圧性ヨード造影剤の作用--造影剤の分配係数の重要性
  • セッケッキュウ ノ ヘンケイノウ ト ケイタイ ニ オヨボス テイ シントウア
  • Importance of CM partition coefficient
  • 造影剤の分配係数の重要性

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The effects of contrast media (CM) on the filterability and morphology of human red blood cells (RBCs) were investigated by testing the impact of CM partition coefficient, as well as CM osmolality and viscosity, using a recently developed nickel mesh filtration method and a differential interference contrast microscope. The low-osmolality CM, iomeprol and iohexol, and the recently synthesized isotonic CM, iotrolan were studied. Among them, the partition coefficient (l-butanol/water) of iotrolan was the smallest; i. e., iomeprol (0.105)>iohexol (0.082)>>iotrolan (0.005). RBCs suspended in iomeprol or iohexol revealed a marked decrease in filterability and several stages of echinocytic shape changes with an increase in incubation time, CM concentration and experimental temperature; the impact of iomeprol was stronger than that of iohexol. However, at the same CM concentration, iotrolan caused very small decrease in filterability and little shape changes even with incubation for 60 minutes at 36°C. The results strongly suggest that the difference of the impact of CM on RBC rheology may arise from the difference of CM partition coefficient. Thus, it can be concluded that CM partition coefficient, as well as CM osmolality and viscosity, is a predominant factor that exerts direct influences on RBC rheology.

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