硝子体の構造とヒアルロナン

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タイトル別名
  • The structure of Vitreous Body and Hyaluronan
  • ショウシタイ ノ コウゾウ ト ヒアルロナン

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説明

The vitreous body is a tenuous gel that contains collagen and hyaluronan. The fraction of the polymer network is only about 1-2%. Thus, about 98-99% of water is sustained within 2% of the polymer network. The vitreous body is located between the lens and the retina that comprises 80% of the overall volume of eye. The functions of the vitreous body are supposed to keep the shape of the eyeball, to absorb the external mechanical shock, to maintain the homoeostasis of the eye, and to regulate the position of the lens. The appearance of fresh vitreous body is transparent, and hence, the vitreous body is considered a uniform tissue. Many studies performed to date have suggested that hyaluronan, which has a coil shape, is uniformly distributed throughout the three-dimensional network of collagen fibers that form the triple helix in the vitreous body. Also, as a macroscopic structure, vitreous body has cistern. Further, the collapse of the vitreous body in the eye may cause many diseases such as posterior vitreous detachment, vitreous bleeding, and retinal detachment. We demonstrate the vitreous substitute that contains hyaluronan and its evaluation.

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