A Case of Drug-induced Hypersensitivity Syndrome with Severe Stomatitis

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  • FUKUSHIMA Yosuke
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University
  • ENOKI Yuichiro
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University
  • YASUI Hirohito
    Department of Dermatology, Faculty of Medicine, Saitama Medical University
  • TAKIGUCHI Kojiro
    Department of Dermatology, Faculty of Medicine, Saitama Medical University
  • NAGASE Yumiko
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University
  • NAKAMOTO Norimichi
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University
  • SATO Tsuyoshi
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University
  • SAKATA Yasuaki
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University
  • YODA Tetsuya
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University

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Other Title
  • 重度口内炎を呈した薬剤性過敏症症候群の1例
  • ショウレイ ホウコク ジュウド コウナイエン オ テイシタ ヤクザイセイ カビンショウ ショウコウグン ノ 1レイ

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Abstract

We report a case of drug-induced hypersensitivity syndrome with severe stomatitis caused by allopurinol. A 82-year-old man had erythema involved the whole body and desquamation on his palms. His lips and buccal mucosa was erosive, his tongue became edematous and bled easily. Bloody desquamated epithelium adhered palatal mucosa, therefore, spontaneous pain and haphalgesia was severe. We used Mazulenin G® with 4%-Xylocaine®, mouthwash as symptomatic therapy, oral pain was controlled enough and ingestion intake was began relatively early.

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