A Study of Ultra-Long-Term Administration of Pilocarpine Hydrochloride in Patients with Xerostomia Due to Sjögren's Syndrome

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  • IWABUCHI Hiroshi
    Department of Oral and Maxillofacial Surgery, Graduate school of dentistry, Kanagawa Dental University Department of Dentistry and Oral Surgery, National Hospital Organization Tochigi Medical Center
  • ISHIDA Takafumi
    Department of Oral and Maxillofacial Surgery, Graduate school of dentistry, Kanagawa Dental University Departmet of Clinical Research, National Hospital Organization Tochigi Medical Center
  • SATO Mariko
    Department of Oral and Maxillofacial Surgery, Graduate school of dentistry, Kanagawa Dental University Departmet of Clinical Research, National Hospital Organization Tochigi Medical Center
  • IWABUCHI Emi
    Department of Dentistry and Oral Surgery, National Hospital Organization Tochigi Medical Center
  • UCHIYAMA Kimio
    Department of Dentistry and Oral Surgery, National Hospital Organization Tochigi Medical Center
  • FUJIBAYASHI Takashi
    Department of Dentistry and Oral Surgery, National Hospital Organization Tochigi Medical Center Kanagawa Dental University
  • KUBOTA Eiro
    Kanagawa Dental University

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Other Title
  • シェーグレン症候群に伴う口腔乾燥症患者に対するピロカルピン塩酸塩の超長期投与例の検討
  • シェーグレン症候群に伴う口腔乾燥症患者に対するピロカルピン塩酸塩の超長期投与例の検討 : 安全性と薬剤耐性の検討
  • シェーグレン ショウコウグン ニ トモナウ コウコウ カンソウショウ カンジャ ニ タイスル ピロカルピン エンサンエン ノ チョウチョウキ トウヨレイ ノ ケントウ : アンゼンセイ ト ヤクザイ タイセイ ノ ケントウ
  • A Study of Ultra-Long-Term Administration of Pilocarpine Hydrochloride in Patients with Xerostomia Due to Sjögren's Syndrome
  • —安全性と薬剤耐性の検討—
  • —An Examination of the Safety and Drug Resistance—

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Abstract

We examined the safety and efficacy of super-long-term pilocarpine hydrochloride administration for oral dryness associated with Sjögren's syndrome. Sixty-two patients administered pilocarpine hydrochloride from October 2007 to March 2009 were assessed 2 or more years after the start of administration. Three cases of heavy sweating were observed 2 or more years after drug initiation. These symptoms were mild, and administration was continued. Furthermore, pre-existing adverse drug reactions showed no aggravation. Abnormal biochemical blood test results were observed in 71.0% of patients (n = 68). All changes were slight, and administration was continued in all patients. Even with continuous administration, the patients showed no symptom aggravation. No significant change in salivary secretion or subjective symptom score was observed in 27 patients after 5 years.

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