D-アミノ酸酸化酵素欠損ddY/DAO-マウスの毛色遺伝子の分析とD-アミノ酸酸化酵素遺伝子と毛色遺伝子との非連鎖〔英文〕

KONNO Ryuichi, YASUMURA Yosihiro

doi:10.1266/jjg.59.159

D-アミノ酸酸化酵素欠損ddY/DAO-マウスの毛色遺伝子の分析とD-アミノ酸酸化酵素遺伝子と毛色遺伝子との非連鎖〔英文〕

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KONNO Ryuichi

Department of Microbiology, Dokkyo University School of Medicine
YASUMURA Yosihiro

Department of Microbiology, Dokkyo University School of Medicine

書誌事項

タイトル別名

Coat color genes of D-amino acid oxidase deficient ddY/DAO- mice and nonlinkage of gene for D-amino acid oxidase to coat color genes.
D アミノサンサンカコウソケッソン ddY DAO マウスノケイロ

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説明

Coat color genes of mutant ddY/DAO^- mice that do not have D-amino acid oxidase were examined by crosses of these mice with NC (AAbbCC) and II TES (aabbCCddss) mice. All the (ddY/DAO^-×NC)F₁ mice had agouti coats and the (ddY/DAO^-×II TES)F₁ mice had black coats. These results indicate that the ddY/DAO^- mice carry aaBBcc DDSS gene.<br>Linkage relationship of Dao-1 gene coding for D-amino acid oxidase to coat color genes was examined. Segregants produced from backcrosses of (ddY/DAO^-×IITES)F₁ with ddY/DAO^- and (ddY/DAO^-×NC)F₁ with ddY/DAO^- were examined for D-amino acid oxidase activity and coat color. F₂ segregants from a (ddY/DAO^-×NC) cross were also studied. These crosses showed that Dao-1 was not linked to a, b or c.