Laserthermia for Head and Neck Cancers

DOI
  • MORIYAMA Ichiro
    Department of Otolaryngology, Faculty of Medicine, Kagoshima University
  • OHYAMA Masaru
    Department of Otolaryngology, Faculty of Medicine, Kagoshima University
  • NOBORI Takuo
    Department of Otolaryngology, Faculty of Medicine, Kagoshima University

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Other Title
  • 頭頸部腫瘍とレーザーハイパーサーミア治療

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The new method of interstitial hyperthermia using Nd: YAG laser, “laserthermia” was developed and used for head and neck malignant tomors. The ceramics laser probe for hyperthermia was inserted into the tumor and laserthermia was carried out for 20 minutes between 41. 5 and 43 degree centigrade. Twenty nude mice which were performed transplantation of anaplastic cell carcinoma obtained from human thyroid lesion were divided into four groups; laserthermia, cisplatin(CDDP), laserthermia combined with CDDP and control. Furthermore based on the experimental study, laserthermia was clinically applied to 21 patients with head and neck malignancies. Ten cases of them were treated as first therapy by laserthermia combined with irradiation before radical operations. Laserthermia was done once a week for five weeks and irradiation two Gy/a day, 50Gy/ 5 weeks. Other 11 cases who had recurrence and metastasis of head and neck tumors after some therapies were treated by laserthermia alone or combination therapies. The following results were obtained from the present study.<BR>1) In the experimental study laserthermia combined with CDDP was most effective<BR>2) In the clinical study, no malignant evidence of the resected speciment was recognized in five cases of laserthermia combined with irradiation group.<BR>3) Laserthermia effectively affected 11 cases with recurrent and metastatic tumors as reduction of volume and local control.

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