Human Isolated Lactobacillus gasseri Colonizes the Intestinal Tract of Rats and Controls the Fecal Flora and Fecal Enzymes

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  • ヒト腸管から分離した<I>Lactobacillus gasseri</I>のラット腸管内でのコロニー化と便中菌叢と酵素活性の制御

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The in vivo role of Lactobacillus gasseri SBT10239 was investigated to elucidate the effect it has on inhibiting coliforms and fecal enzymes such as β-glucuronidase and β-glucosidase, which are known to metabolically activate carcinogenic compounds in the intestine. L. gasseri SBT10239colonized the intestinal tract of rats and continued to control fecal flora, even after termination of the administration of lactic acid bacteria. The administration of L. gasseri SBT10239 in rats also resulted in significant (P<0.01) inhibition of coliforms and anaerobes. The activity of the fecal enzymes β-glucosidase and β-glucuronidase also decreased significantly (P<0.001) and this correlated well with the decreased number of coliforms and anaerobes found in the intestinal tracts of the rats. Moreover, this strain was able to colonize the intestinal tracts of the rats.

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