Arginine Imbalanced Dietによる発癌抑制に関する実験的研究

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タイトル別名
  • Inhibitory Effect of Arginine-Supplemented Diets upon Mammary Carcinogenesis
  • Arginine Imbalanced Dietによる発癌抑制に関する実験的研究-1-DMBAによる乳癌の誘発に対するArginine Imbalanced Dietの影響
  • Arginine Imbalanced Diet ニヨル ハツガン ヨクセイ
  • Part 1 Influence of Arginine-Supplemented Diets on Rat Mammary Carcinogenesis Induced by 7, 1 2-DMBA
  • 第1編DMBAによる乳癌の誘発に対するArginine Imbalanced Dietの影響

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It has recently been shown that certain amino acid imbalances in the diet inhibit the incidence and growth of tumors.<BR>This report describes the effect of excess arginine in the diet of rats with mammary carcinoma induced by 7,12-DMBA. The diets contained equal quantities of carbohydrate, fat, vitamins and minerals and differed only in protein content;<BR>1) MF diet (Oriental Yeast Co. )<BR>2) 20% casein (control)<BR>3) 15% casein supplemented with 5% arginine<BR>4) 12% casein supplemented with 8% arginine<BR>A fat emulsion of 7,12-DMBA (3mg DMBA per rat) was injected intravenously into the tail vein of female Sprague-Dawley rats at 55 and 58 days of age. The animals were examined every day during the experimental period, and the number and size of the palpable tumors were recorded. All rats were sacrificed at 145 days of age and examined grossly and microscopically.<BR>In the first experiment,40 day-old rats were fed on one of the four diets before and after DMBA-injection, respectively. The mean weight gain in the four groups was the same each other, and no side effects of arginine were noted. A decrease in incidence, a delayed onset and a lower number of tumors were observed in the groups fed argininesupplementd diets. Tumor formation in the MF diet group was almost the same as in the 20% casein diet group.<BR>In the second experiment, three groups of 40 day-old rats were fed on control or arginine-supplemented diets before and for 35 days after the injection of DMBA. Then they all received the MF diet. The incidence, incubation time and average number of tumors were the same in all three groups.<BR>In the third experiment, the MF diet was fed to all groups for 15 days before DMBAinjection, and starting 35 days after DMBA-injection, the control or arginine-supplemented diets were substituted. The tumor incidence was lower in the arginine-supplemented diet groups, but the difference was not statistically significant. However, a prolonged incubation time and fewer tumor were observed, as in the first experiment.<BR>The above data indicate that arginine-supplemented diets have little or no effect on the initiating stage of DMBA-induced mammary carcinogenesis, but they distinctly effect on the promoting stage.<BR>Both the urea concentration and arginase activity in rat mammary fat pads and the urea content of mammary tumors induced by DMBA were examined.<BR>Urea concentrations and arginase activities were increased in rats fed arginine-, supplemented diets.<BR>This suggests that urea in mammary tissue may play an important role in rat mammary carcinogenesis.<BR>Further studies will be reported in another paper.

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