“Pseudo-Heart-Failure Cell”生成に関する実験的研究

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タイトル別名
  • Histochemical Studies on Experimentally Produced“Pseudo-Heart-Failure Cell Pigment”
  • Pseudo Heart Failure Cell セイセイ ニ カンスル ジ
  • Histochemical Studies on Experimentally Produced^|^ldquo;Pseudo-Heart-Failure Cell Pigment^|^rdquo;

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Attempted was the experimental production of“pseudo-heart-failure cell pigment”so named, because of its iron-negative reaction, by Maeda et al. to ceroid-like pigment found with or without hemosiderin in some of human pulmonary macrophages.<BR>A kind of this pigment could be histochemically identified, although at a lower frequency, in macrophages in both the alveolar walls and spaces of part of the laboratory animals used, that is, rats either fed a vitamin E-deficient diet for 4 months to one year and a half, a diet containing 0.06% butter yellow for 40 days to 10 months, or completely deprived of food for one to two weeks.<BR>It was noticed that fluorescent microscopy proved to be quite effective in detecting relatively small amounts of“pseudo-heart-failure cell pigment”coexisting with large amounts of hemosiderin in the same macrophages by confirming the autofluorescence of the pigment.<BR>On this occasion, it was suggested on the basis of the results of the carmine vital staining etc. that chronic pulmonary edema caused by an increased permeability of the walls of the pulmonary alveolar capillaries as well as increased amounts of plasma protein fractions (probably abnormal glycoprotein) in the blood induced by hemolysis in vitamin E-deficient rats or by prominent consumption of general tissue proteins in rats completely deprived of food for a certain period would participate in the mechanism of the experimental production of“pseudo-heart-failure cell pigment”in pulmonary macrophages.

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