副腎皮質腫瘍に関する実験病理学的研究

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  • Experimental Studies on Adrenocortical Tumors in C<SUB>3</SUB>H/He Female Mice
  • フクジン ヒシツ シュヨウ ニ カンスル ジッケン ビョウリガクテキ ケンキュ
  • Experimental Studies on Adrenocortical Tumors in C3H/He Female Mice

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Spontaneous adrenocortical tumors appear to be rare in popular strains of mice, and above all, the development of hormone-producing adrenocortical tumors are extremely seldom. In order to carry out the induction of functional adrenocortical tumors, a total of 94 C3H/He virgin mice were divided into the following 4 experimental groups; (1) 16 mice of the age of 6-9 weeks were applied to the untreated control group, (2) 18 mice received an intravenous injection of 2.5 mg of 7,12-Dimethylbenz (a) anthracene (DMBA) twice at the ages of 10-12 and 13-14 weeks in the carcinogen-treated group, (3) 17 mice were ovariectomized bilaterally at the age of 6-9 weeks in the ovariectomized group, (4) 43 mice were ovariectomized bilaterally at the age of 6-9 weeks, and then injected intravenously with 2.5mg of DMBA emulsion at the ages of 10-12 and 13-14 weeks, respectively, in the ovariectomized and DMBA-injected (combination-treated) group. The experimental animals survived more than the age of 7 months were determined to be effective for this tumorigenesis.<BR>Adrenocortical tumors were found unilaterally in some treated mice, and their weights were distributed in the range of 20-1600 mg. The incidences of adrenocertical tumors in the effective animals were as follows: 0 /12= 0% on the control group,1 /13=7.7% on the DMBA-injected group,1 /15=6.7% on the ovariectomized group, and 10/21=47.6% on the combination-treated group. Many mammary tumors with few pulmonary metastasis were observed in the non-operated mice, and some ovarian tumors were detected in the injected mice. Few leukemia, thymoma and lung tumors could be seen in the treated groups. In brief, double administrations of DMBA emulsion in several weeks after the bilateral ovariectomy might evoke more often a neoplastic transformation in the adrenocortical cells of C3H/He virgin mice.

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