Sulpirideの乳腺刺激作用に関する研究

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タイトル別名
  • Studies on Mammotrophic Action of Sulpiride Part I Morphological Observations on Mammotrophic Action of Sulpiride in Rats
  • Sulpirideの乳腺刺激作用に関する研究-1-Sulpirideの乳腺刺激作用に関する形態学的観察
  • Sulpiride ノ ニュウセン シゲキ サヨウ ニカンスルケンキュウ 1
  • 第1編 Sulpirideの乳腺刺激作用に関する形態学的観察

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Both sexes of Sprague-Dawley JCL rats, aged 8∼9 weeks and weighing 200∼250g, were injected subcutaneously by either 100mg/kg or 200mg/kg of Sulpiride daily for 1 month. In females treated with Sulpiride, a marked proliferation with severe milk secretion could be observed on the mammary glands. The weight of abdominal mammary fatty pads increased twice. Their endocrine glands could reveal no prominent changes. The sexrelated organs, especially the uterus, were somewhat atrophic. In males injected by Sulpiride, the similar changes could be detected, but they were weaker than females.<BR>Adult female Sprague-Dawley JCL rats, some of which were given orally 1000mg/kg of Sulpiride daily in definite periods, were checked their vaginal smears every early morning. All treated rats revealed to begin a continuous diestrous state in a week after the first intubation and to stop a diestrous condition in a week after the last intubation. The mammary glands of the females treated for 70∼90 days were prominently proliferative and hypersecretory, and they revealed a severe milk stasis with yellow pigment deposition. A marked atrophy with fibrosis could be detected in the mammary fatty tissues 3 weeks after the ceasation of daily intubation, when the cycles of vaginal smear returned to be regular.<BR>By means of Khazan et al. 's index, the mammotrophic activity of Sulpiride was compared with that of Chlorpromazine. The effect of subctaneous injection of Sulpiride,100mg/kg, daily for 5 days upon the estrogenized females was corresponded to that of Chlorpromazine,5mg/kg.<BR>Electron-microscopic observations were carried out on the mammary glands of diestrous female rats within 1 day after a subcutaneous injection of Sulpiride,100mg/kg. Secretory pictures, e. g. increase of ribosomes, many secretory granules in the swollen ER, Golgi apparatus and lumen, could be detected 6 hours after the injection. These findings were more prominent 12 and 24 hours after the single injection. The early effect -Irug were recognized morphologically in a week of the daily injection by proliferation of the epithelium with intercellular gaps, and by desquamation of superficial acinar cells. The content of ribosomes in the cytoplasm increased. Many bigger fat droplets and large swollen mitochondria exhibited in the perikaryon. Retention of secretion followed on the continuous stimulation. Such a milk stasis evoked definite degenerative and atrophic alterations in some mammary parenchyms.

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