Investigation on Pharmacokinetics of Meloxicam in Dialysis Patients

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  • Kajiura T
    Department of Internal Medicine, Kansai Medical University
  • Isami Y
    Department of Internal Medicine, Kansai Medical University
  • Katsura K
    Department of Internal Medicine, Kansai Medical University
  • N Inami
    Department of Internal Medicine, Kansai Medical University
  • Kanazawa S
    Department of Internal Medicine, Kansai Medical University
  • Yamada K
    Department of Internal Medicine, Kansai Medical University
  • Kitano T
    Department of Internal Medicine, Kansai Medical University
  • Okamoto M
    Department of Internal Medicine, Kansai Medical University
  • Muramatsu M
    Department of Internal Medicine, Kansai Medical University
  • Ono T
    Department of Internal Medicine, Kansai Medical University
  • Omiya M
    Department of Internal Medicine, Kansai Medical University
  • Tagawa Y
    Department of Internal Medicine, Kansai Medical University
  • Takaoka M
    Department of Internal Medicine, Kansai Medical University
  • Fujii T
    Department of Internal Medicine, Kansai Medical University
  • Nakamori H
    Department of Internal Medicine, Kansai Medical University
  • N Takahashi
    Department of Internal Medicine, Kansai Medical University
  • Fujimoto M
    Department of Internal Medicine, Kansai Medical University
  • Tsuda N
    Department of Internal Medicine, Kansai Medical University

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Considering that dialysis patients are often elderly, the onset risk of gastric mucosa disorder is increased in them. Therefore, the use of a selective cyclooxigenase (COX)-2 inhibitor that is expected to reduce the digestive disorders in the dialysis patients is of great significance. We investigated pharmacokinetics of meloxicam which is a selective COX-2 inhibitor approved in over 100 countries including Japan. Nine renal patients (4 males and 5 females) on hemodialysis were investigated. Single oral administration of meloxicam was conducted after supper the day before dialysis and plasma consentration was determined. The blood was taken at 1 hour, before start of dialysis. The meloxicam concentratio n was analysed by ultrafiltration. The mean plasma meloxicam concentration (meant-SD) at 1 hour before start of dialysis and at 1,4 and 48 hours after the start of dialysis were 541±168 ng/ml,532±153,512± 161,42± 72, respectively. The re sults indicated not significant changes in the plasma concentration at 1 and 4 hours after start of dialysis.

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