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- Semba Reiji
- Institute for Developmental Research, Aichi Prefectural Colony
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- Yamamura Hideki
- Institute for Developmental Research, Aichi Prefectural Colony
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- Murakami Ujihiro
- Institute for Developmental Research, Aichi Prefectural Colony
書誌事項
- タイトル別名
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- Effect of Cadmium Pretreatment on Terat
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Pretreatment with cadmiu m is reported to protect animals, to some extent, from acute toxicity of a following administration of a higher dose of cadmium itself. On the other hand, it is still unknown as to whether or not the teratogenicity and/or the fetolethality of cadmium are reduced by such pretreatment with cadmium. Based on a report that administrations of cadmium sulfate to pregnant mice on their 7th day of gestation caused exencephaly and death of their fetuses, the authors investigated possible prevention of teratogenic and fetolethal effects of cadmium by pretreatment with a smaller dose of cadmium. On day 6 of gestation, a low dose (0.5 mg/kg or 1 mg/kg)of cadmium fulfate was administered intraperitoneally (ip) or subcutaneously (sc) to pregnant JCL: ICR mice, and on the next day a high dose (5 mg/kg) of the same compound was administered ip. Dams were sacrificed on day 17 of gestation and con. ceptuses were examined. A dose of 0.5 mg/kg of cadmium ip failed to show a protective effect against teratogenicity, but 1 mg/kg sc or 1 mg/kg ip was effective. However, induction of exencephaly was not completely blocked by these pretreatments. On the other hand, the protective effect against fetolethality was remarkable and fetal death rates were significantly lowered by overall pretreatment to control values.
収録刊行物
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- Okajimas Folia Anatomica Japonica
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Okajimas Folia Anatomica Japonica 54 (5), 283-287, 1977
Editorial Board of Okajimas Folia Anatomica Japonica
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詳細情報 詳細情報について
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- CRID
- 1390282680436740992
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- NII論文ID
- 130004650028
- 40005304830
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- NII書誌ID
- AA00331003
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- COI
- 1:CAS:528:DyaE1cXhs1Gjtb4%3D
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- NDL書誌ID
- 1916911
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- ISSN
- 0030154X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可