<b>Photo-Dimerization Induced Dynamic Viscoelastic Changes in ABA Triblock Copolymer-Based Hydrogels for Three-Dimensional Cell Culture </b>

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  • <b>光二量化により粘弾性を変化できるABA トリブロックコポリマーを基盤とした </b><b>動的ハイドロゲルの創製と三次元細胞培養への応用 </b>
  • 光二量化により粘弾性を変化できるABAトリブロックコポリマーを基盤とした動的ハイドロゲルの創製と三次元細胞培養への応用
  • コウジリョウカ ニ ヨリ ネンダンセイ オ ヘンカ デキル ABA トリブロックコポリマー オ キバン ト シタ ドウテキ ハイドロゲル ノ ソウセイ ト サンジゲン サイボウ バイヨウ エ ノ オウヨウ

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Abstract

<p>In this study, we report a cytocompatible and dynamic hydrogel comprised of well-defined ABA triblock copolymers, which enable significant changes of viscoelastic properties only by UV light irradiation. The thermo-responsive A block contains N-isopropylacrylamide and an acrylate monomer with a coumarin side chain, whereas the hydrophilic B block is biocompatible poly(ethylene oxide). With increasing temperature, the triblock copolymer undergoes a sol-to-gel transition and forms a physically cross-linked hydrogel under physiologically relevant conditions. Furthermore, under UV light irradiation, the viscoelasticity of the hydrogel is dynamically modulated because of the photo-dimerization of coumarin moieties. After UV light illumination, viscoelastic properties of the hydrogel are significantly different, indicating the formation of chemical cross-linking points in the micelle core. Finally, we demonstrate that the dynamic changes in the viscoelasticity of the hydrogel have a large influence on the proliferation behavior of encapsulated cells.</p>

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