Cytokeratin (CK 7, CK 20) and MUC 5 AC expression in ampullary carcinoma
-
- SONOUE Hiroshi
- First Department of Pathology, Juntendo University, School of Medicine
-
- SUDA Koichi
- First Department of Pathology, Juntendo University, School of Medicine
-
- NOBUKAWA Bunsei
- First Department of Pathology, Juntendo University, School of Medicine
-
- ABE Hiroshi
- First Department of Pathology, Juntendo University, School of Medicine
Bibliographic Information
- Other Title
-
- 十二指腸乳頭部癌におけるCK 7, CK 20, およびMUC 5 ACの免疫組織化学的検討
Search this article
Abstract
Ampullary carcinoma can be divided into the pancreatobiliary differentiation and intestinal phenotypes. The former is usually invasive and has a lower 5-year survival rate. In this study, ampullary carcinoma was immunohistochemically investigated by cytokeratins (CKs) and MUC 5 AC, which were found in the non-tumorous duodenal papilla and so-called overreplacement, or distended glands of the duodenum, respectively. Ampullary carcinoma specimens were obtained from 16 patients who underwent pancreatoduodenectomy. Immunoreactivities for both CK 7 and CK 20 as well as MUC 5 AC were found in 11 and 9 of the 16 cases, respectively. Among these positive specimens, CK 7 and CK 20 demonstrated reverse immunoreactivity in 4 cases each,8 cases in total, with both being immunopositive in 7 cases and both immunonegative in one case that was positive for MUC 5 AC. Immunoreactivity for MUC 5 AC and CK 7 was coincident in 12 cases, while the coincidence for MUC 5 AC and CK 20 was obtained only in 4 cases. Therefore, ampullary carcinoma showed various phenotypes, as follows: pancreatobiliary differentiation in 4 and intestinal phenotype in 4, dual immunoreactivity as described above in 7 and dual negativity in one.
Journal
-
- Tando
-
Tando 20 (4), 473-478, 2006
Japan Biliary Association
- Tweet
Details 詳細情報について
-
- CRID
- 1390282680442150528
-
- NII Article ID
- 10031122797
-
- NII Book ID
- AN10062001
-
- ISSN
- 09140077
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed