Glyceryl Trinitrate(ニトログリセリン)の胆道内投与の胆道機能におよぼす効果と臨床応用

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  • Effect of billiary tract administration of Glyceryl Trinitrate (GTN)on biliary function and the clinical application of GTN for gallstone treatment

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The effects in 15 surgical cases of glyceryl Trinitrate (GTN), a new relaxant of the sphincter of Oddi, on biliary function were examined. The sphincter of Oddi was to be completely relaxed and biliary pressure decreased after direct infusion of GTN into the common bile duct. We attempted to eliminate gallstones in patients with residual stones and choledocholithiasis by perfusion of saline solution containing GTN (10 mg) into the common bile duct while using a biliary drainage tube. In 3 of 4 cases, gallstones were eliminated from the biliary tract. No side effects, such as abdominal pain and decreased blood pressure, were observed. Since this treatment can be performed safely and repeatedly, we believe that it is a useful method in the management of common bile duct stones in patients with biliary drainage.

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  • Tando

    Tando 4 (4), 443-450, 1990

    Japan Biliary Association

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