STUDIES ON THE MODE OF EXCRETION OF CHEMOTHERAPEUTIC AGENTS IN UNILATERAL RENAL DYSFUNCTION

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  • 片腎障害時における薬剤の排泄動態について
  • カタ ジン ショウガイ ジ ニ オケル ヤクザイ ノ ハイセツ ドウタイ ニ ツイテ

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1. Differential renal function test was performed by ureteral catheterization on 33 cases with unilateral disturbance of renal function and the excretion of various chemotherapeutic agents was studied. The results summerized as follows:<br>a) Creatinin clearance (Ccr) of affected kidney/total Ccr was proved to correlate to PAH clearance (CPAH) of affected kidney/total CPAH. Therefore Ccr was selected as an indicator representin t excretory function.<br>b) Unaffected kidney compensated the affected kidney by drug excretion test.<br>c) Though it has been generally accepted that Cdrug (drug clearance)/Ccr is constant, it was suggested that Cdrug/Ccr of affected kidney was lower than that of unaffected one, according to the degree of damage.<br>2. No remarkable difference was obtained in Cdrug/CPAH between unaffected and affected kidney by the experimental unilateral stricture of renal artery.<br>3. Analysis of urinary concentration and recovery of drug was performed from the pharmacodynamic standpoint.

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