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- 上田 豊史
- 九州大学医学部泌尿器科
書誌事項
- タイトル別名
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- A HISTOCHEMICAL STUDY OF PROXIMAL TUBULAR CELLS IN EXPERIMENTAL TUBULAR NECROSIS IN THE RAT KIDNEY
- ジッケンテキ キュウセイ ニョウ サイカン エシ ノ ソシキ カガクテキ ケンキュウ
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抄録
The present experiments were carried out with an object to morphologically examine the changes of some enzymes of proximal tubular cells when renal tubular necrosis induced by Mercury, Glycerol and Kanamycin (KM) with 10% Low-Molecular-Dextran (LMWD).<br>The results were summarized as follows:<br>1) The degeneration and necrosis of proximal tubular cells were observed 24 houres after administration of Mercury, Glycerol and KM-LMWD.<br>2) Three hours after administration of Glycerol, the appearance and formal change of formazan deposits and the decrease of succinic dehydrogenese activity in proximal tubular cells were observed.<br>3) Three hours after administration of Mercury, histochemical change of succinic dehydrogenese was the same as in Glycerol renal injury, but that of glucose-6-phosphatase was particular evident, so that aggregated droplets which had glucose-6-phosphatase activity appeared in proximal tubular cells.<br>4) Six hours after administration of KM-LMWD, the decrease of acid-phosphatase locality and the absence of acid-phosphatase activity within vacuoles were observed. The above results indicate that tubular necrosis following Glycerol is mitochondrial origin, tubular necrosis following Mercury is a primary disturbance of microsome and secondary disturbance of mitochondria due to anoxia, and tubular necrosis following KM-LMWD is the release of lysosomal enzyme due to autolysis.
収録刊行物
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- The Japanese Journal of Urology
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The Japanese Journal of Urology 65 (1), 18-28, 1974
社団法人 日本泌尿器科学会
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詳細情報 詳細情報について
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- CRID
- 1390282680454233216
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- NII論文ID
- 130006934348
- 110003047753
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- NII書誌ID
- AN00196577
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- ISSN
- 18847110
- 00215287
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- NDL書誌ID
- 7623690
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- データソース種別
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- JaLC
- NDL
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