METABOLISM OF MUCOUS MEMBRANE OF ALIMENTARY TRACTS AND ITS CLINICAL SIGNIFICANCE

1) We studied non-hemin iron metabolism, nucleic acid metabolism and also acid soluble phosphorus metabolism of mucous membrane of alimentary tracts using radioactive isotope Fe⁵⁹as well as P³², contrasting them to those of liver. And the curve of normal turn over rate was obtained.<BR>2) We observed the transition of these mucous membrane metabolism, having administered anti-cancerous chemicals, vitamines, hormones or some chemicals which accelerate or inhibit these metabolism.<BR>3) Mucous membrane of alimentarytracts takes an important part not only in absorbing iron but also in non-hemin iron metabolism and is closely related to iron metabolism of the hematopoietic organs.<BR>4) In non-hemin iron metabolism of the mucous membrane of alimentary tracts ferritin works the most important part.<BR>5) In nucleic acid metabolism we were shown the different value of the relative specific activity of D.N.A. or R.N.A. according to the methods, Schmidt-Thannbauser's and Davidson's. But between these two methods there was seen no difference in thetendency of the normal turn over rate curves and also the reaction by chemicals showed thesame tendency.<BR>6) Nucleic acid metabolism of intestinal mucosa showed the higher value than that of gastric mucosa.<BR>7) In nucleic acid metabolism serum inorganic phosphorus can be thought to be a precursor of total phosphorus, acid soluble inorganic phosphorus andacid soluble total phsophorus.<BR>8) In intestinal mucosa, metabolism of acid soluble phosphorus fractions is extremely high, and especially glycerophosphoric acid, propanediol andcoenzyme showed the higher value than in liver.<BR>9) The turn over rate curves of glucose-l-phosphate and of phosphoglyceric acid cross the curve of specific activity of serum inorganic phosphate at their heights.<BR>10) The organ which shows high turn over rate in adenylic acid system such as propanediol, coenzyme, adenylic acid, stable P of ATP-ADP and labile P of ATP-ADP and ladile P of ATP-ADP, has also high turn over rate in nucleic acid metabolism.<BR>11) The mucous membrane of alimentary tracts plays an important role upon phosphorus metabolism of the whole body, closely relating with nucleic acid metabolismand phosphorus metabolism of liver.<BR>12) Each chemical seems to possess organ-affinity or fractionaffinity and differsin reacting mechanism according to the kind of organs and to its fractions.<BR>13) As a whole, anti-cancerous chemicals inhibit non-hemin iron metabolism andnucleic acid metabolism but acid soluble phosphorus metabolism is not neccessarily inhibited by them. As for the anticancerous chemicals like Azan or Nitromin that inhibit metabolism in every fraction, the administration by small dosage should be studied from the view point of organ and fraction affinities.<BR>14) Vitamin B₁₂ and Folic acid seem to accelerate nucleic acid metabolism but Vitamin C is still under our problem.<BR>15) NaHCO₃and HCl accelerate acid soluble phosphorus fraction. 16) ACTH and Cortisone inhibit non-hemin iron metabolism but accelerate nucleic acid and acid soluble phosphorus metabolism.<BR>17) Nucleton accelerates non-hemin iron metabolism, nucleic acid metabolism and acid soluble phosphorus metabolism. Ampesin accelerates phosphoprotein metabolism but in other fractions the conclusion is not yet given. Achromycin inhibits nucleic acid metabolism but sometimes accelerates acid soluble phosphorus metabolism conversely.<BR>18) So-called antagonist does not always react antagonistically in every fraction.<BR>19) In the caseof patients with gastric cancer who have shown good clinical prognosis, nucleic acid metabolism of cancer tissue is conspicuously inhibited after administration of anti-cancerous chemicals, such as Sarcomycin and Nitromin.