Clinical Significance of Minor Histocompatibility Antigens in Allogeneic Stem Cell Transplantation

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  • Murata Makoto
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine

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  • 第2回 同種造血幹細胞移植におけるマイナー組織適合性抗原の臨床的意義

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<p>Minor histocompatibility antigens consist of HLA-bound peptides derived from cellular proteins encoded by polymorphic genes that differ between transplant donor and recipient. More than 20 of human minor histocompatibility antigens have been molecularly characterized. In HLA-matched hematopoietic stem cell transplantation, donor T cell recognition of recipient minor histocompatibility antigens is responsible for graft-versus-host disease and the graft-versus-tumor effect.</p>

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