Immune-mediated Necrotizing Myopathy (IMNM) and HLA Polymorphisms

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  • Ohnuki Yuko
    Department of Molecular Life Science, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
  • Suzuki Shigeaki
    Department of Neurology, Keio University School of Medicine
  • Shigenari Atsuko
    Department of Molecular Life Science, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
  • Suzuki Shingo
    Department of Molecular Life Science, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
  • Suzuki Norihiro
    Department of Neurology, Keio University School of Medicine
  • Nishino Ichizo
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
  • Shiina Takashi
    Department of Molecular Life Science, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine

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  • 免疫介在性壊死性ミオパチー（IMNM）とHLA多型

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<p>Immune-mediated necrotizing myopathy (IMNM) is a relatively newly recognized subgroup of idiopathic inflammatory myopathies. Although it has similar symptoms to polymyositis clinically, IMNM is distinguished from the other inflammatory myopathies by the absence of prominent inflammatory infiltrates histologically. IMNM has been known to be associated with myositis-specific autoantibodies such as anti-SRP and anti-HMGCR antibodies. It also may be associated with statin, malignancy and connective tissue diseases. This review provides an overview of IMNM and describes our study analyzed alleles of HLA-A, B, C, DRB1 in IMNM patients.</p>

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