Analysis of HLA haplotypes in Japanese, using high resolution allele typing

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Other Title
  • 日本人の4桁レベルのHLAハブロタイブ分布
  • Analaysis of HLA haplotypes in Japanese, using high resolution allele typing.
  • Analysis of HLA haplotypes in Japanese, using high resolution allele typing [in Japanese]
  • [Analysis of HLA haplotypes in Japanes, using high resolution allele typing

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<p>We have analyzed HLA haplotypes in Japanese, using high resolution allele typing for 8 loci of HLA-A,-C,-B,DRB1,-DRB345,-DQA1,-DQB1,-DPB1. It is a purpose to identify linkages between alleles unidentified by the serologicalumethod such as A*0201 or A*0206 and those of other loci. We presented the data of haplotypes inclading alleles with comparatively low frequency. Unique linkage disequilibria were recognized in A2, A26, B13, B44, B61, B62, B39 and C locus with serologically “blank” alleles in the class I region. Tight linkages between DR-DQ were confirmed in the HLA class II region, weaker but significant linkages to DPB1 were also recognized.</p>

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