THERAPEUTIC EFFECTS OF MICRONOMICIN ON MOUSE PROTECTION TESTS BY INTRAVENOUS ADMINISTRATION
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- SATO KIYOSHI
- Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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- YAMASHITA KINYA
- Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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- OKACHI RYO
- Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
Bibliographic Information
- Other Title
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- Micronomicinの静脈内投与によるマウス実験感染症に対する治療効果
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Abstract
Protective effects of intravenous administration of micronomicin (MCR) on mouse experimental infections were investigated.<BR>Mice were better protected by intravenous administration in S. marcescens T-55 experimental infection than subcutaneous administration. No remarkable differences were found between the two administrations in cases of P. aeruginosa BMH No.1 and E. coli GN 2411-5 infections.<BR>Intravenous administrations of MCR, gentamicin (GM), dibekacin (DKB), amikacin (AMK) and sisomicin (SISO) protected the infection of P. aeruginosa BMH No.1 in a similar extent. MCR was more effective intravenously than AMK; DKB and AMK; DKB, AMK and SISO in experimental infections of E. coli GN 2411-5; S. marcescens T-55; P. aeruginosa KY-8510 harboring aminoglycoside inactivating enzyme AAC (6')-4, respectively.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 36 (11), 3277-3282, 1983
Japan Antibiotics Research Association