FUNDAMENTAL AND CLINICAL EVALUATION OF CEFOXITIN IN CHILDREN

DOI Web Site PubMed

Bibliographic Information

Other Title
  • 小児科領域におけるCefoxitinの基礎的, 臨床的検討
  • ショウニカ リョウイキ ニ オケル Cefoxitin ノ キソテキ リンショ

Search this article

Abstract

Fundamental and clinical evaluations were made on cefoxitin, a new cephamycin antibiotic, and the following results were obtained.<BR>1) MIC of the drug to clinical isolates was determined and was higher than that of cefazolin to Gram-positive bacilli. Among Gram-negative rods, the drug howed a sufficient antibacterial activity even to cefazolin-resistant strains. However, the MIC of cefoxitin to cefazolin-sensitive strains tended to be higher than that of cefazolin.<BR>2) As to the passage of cefoxitin in experimental staphylococcal meningitis in rabbits, a percentage of CSF/serum ratio of AUC was 10.7% up to 3hours and CSF/serum ratio of T1/2 was 1.78, of which value was an intermediate between those of ampicillin and cefazolin. There were, however, larger individual differences.<BR>3) Blood concentrations and urinary recovery rates were determined in 2 children. In 1 patient, in whom the drug was given intravenously at a dose of 25mg/kg, a blood concentration after 30 minutes was 50μg/ml, T1/2 was 57.2 minutes. This patient, however, showed a slight renal dysfunction. In another patient, who received an intravenous injection of 12.5mg/kg, a 30minutes blood concentration was 14.6μg/ml and T1/2 was 31.8minutes. Urinary recovery rates up to 6hours were 85.8% and 73.5%, respectively.<BR>4) Thirty patients with the following bacterial infections were treated with cefoxitin, i.e., urinary tract infection (24 cases), respiratory tract infection (4 cases), each one case of peritonitis and suspected sepsis. An overall efficacy rate was 93.3%, i.e., excellent in 13 cases, good in 15, and failure in 2. Disappearance rate of the causative organism of the 23 clinical isolates was 87.0%, i.e., that the causative organism disappeared in 20 strains, reduced in 1 and persisted in 2.<BR>5) Based on the above results, it was concluded that cefoxitin is a potent new antibiotic in bacterial infections in children, particularly respiratory and urinary tract infections. The optimal recommended dose will be about 25mg/kg which should be given 3-4times daily intravenously or by drip infusion.

Journal

Details 詳細情報について

Report a problem

Back to top