CLINICAL EXPERIENCE WITH CEFOPERAZONE IN BRONCHOPULMONARY INFECTIONS AND STUDIES ON ITS PENETRATION INTO PLEURAL EFFUSION
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- KAJIKI AKIRA
- The Second Department of Internal Medicine, University of Occupational and Environmental Health
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- YAMAZAKI HIROSHI
- The Second Department of Internal Medicine, University of Occupational and Environmental Health
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- HASEGAWA OSAMU
- The Second Department of Internal Medicine, University of Occupational and Environmental Health
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- NAKASHIMA YASUHIDE
- The Second Department of Internal Medicine, University of Occupational and Environmental Health
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- KUROIWA AKIO
- The Second Department of Internal Medicine, University of Occupational and Environmental Health
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- HARADA SUSUMU
- The Second Department of Internal Medicine, University of Occupational and Environmental Health
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- KIDO MASAMITSU
- Respiratory Division, University of Occupational and Environmental Health
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- IIDA KYOKO
- Department of Microbiology, Saga Medical School
Bibliographic Information
- Other Title
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- 呼吸器感染症に対するCefoperazoneの臨床使用経験及び胸水中移行に関する研究
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Abstract
Patients with bronchopulmonary infections were treated with cefoperazone (CPZ), and the serum and pleural effusion concentrations were determined after 2 g CPZ drip infusion.The following results were obtained:<BR>1. Eight of 10 patients treated with CPZ responded with a significant clinical improvement.<BR>2. Side effects were found in 4 cases; eruption in 1 case, fever and granulocytopenia in 1 case, elevation of GPT in 1 case, and thrombocytopenia in 1 case.But these side effects disappeared immediately after cessation of CPZ treatment.<BR>3. Intravenous drip infusion of 2g CPZ yielded a peak serum concentration of 112.0-210.0μg/ml immediately after the end of drip infusion, and a peak pleural effusion concentration of 8.8-43.0μg/ml at 2-6 hours after the end of drip infusion.<BR>4. The ratio of peak pleural effusion concentration to peak serum concentration was 4.4-26.9%.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 36 (12), 3456-3462, 1983
Japan Antibiotics Research Association