CLINICAL STUDIES ON LATAMOXEF OF OXACEPHEM ANTIBIOTICS, ESPECIALLY CONCENTRATION OF LATAMOXEF IN LUNG TISSUES AND PROPHYLAXIS OF INFECTIONS AFTER THORACOTOMY

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  • IMAIZUMI MUNEHISA
    The 2nd Department of Surgery, Nagoya University School of Medicine
  • KIMURA JIRO
    The 2nd Department of Surgery, Nagoya University School of Medicine
  • AKIYAMA SEIJI
    The 2nd Department of Surgery, Nagoya University School of Medicine
  • UCHIDA TATSUO
    The 2nd Department of Surgery, Nagoya University School of Medicine
  • ICHIMURA ITARU
    The 2nd Department of Surgery, Nagoya University School of Medicine
  • HIRAI KOZO
    The 2nd Department of Surgery, Nagoya University School of Medicine
  • KAWAHARA KATSUHIKO
    The 2nd Department of Surgery, Nagoya University School of Medicine
  • KONDO TATSUHEI
    The 2nd Department of Surgery, Nagoya University School of Medicine

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Other Title
  • Oxacephem系抗生剤Latamoxefの臨床的検討, 特に肺組織内移行と術後感染予防
  • Oxacephemケイ コウセイザイ Latamoxef ノ リンショウテキ

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There are few clinical reports about concentration of latamoxef (LMOX) in lung tissues. At present, clinically, we report a concentration of LMOX in serum and lung tissues on 21 patients of chest disease and a study of the administration schedule of LMOX for prophylaxis of postoperative infections on 31 operated patients with chest disease. Our results are the followings:<BR>1. The peak concentration of LMOX in serum is 77.4μg/ml at 1hour after starting drip infusion of LMOX 1g.<BR>2. The concentration of LMOX in lung tissues is from 25% to 50% of serum level.<BR>3. LMOX is more useful to prophylaxis of postoperative infections after thoracotomy than cephalothin, especially in case of administration of LMOX just before operation.<BR>4. No side effects of LMOX are noted in our cases.<BR>5. LMOX has wide antibacterial activity against various clinical isolates and is useful to treatment of postoperative infections.

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