FUNDAMENTAL AND CLINICAL STUDIES OF T-1982 (CEFBUPERAZONE) IN THE FIELD OF OBSTETRICS AND GYNECOLOGY
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- IKEDA MASANORI
- Department of Obstetrics and Gynecology, Kinki University, School of Medicine
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- TESHIMA KENSAKU
- Department of Obstetrics and Gynecology, Kinki University, School of Medicine
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- NODA KIICHIRO
- Department of Obstetrics and Gynecology, Kinki University, School of Medicine
Bibliographic Information
- Other Title
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- 産婦人科領域における T-1982 (Cefbuperazone) の基礎的・臨床的検討
- サンフジンカ リョウイキ ニ オケル T 1982 Cefbuperazone
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Abstract
1. Tissue concentrations of T-1982 (cefbuperazone) at 100-220 minutes after the completion of 1g/60 minutes dripping infusion were 8.9-10.6μg/g in the uterus, ovary and oviduct. These concentrations were higher than 80% MIC of the causative organisms, including E. coli, K. pneumoniae, P. mirabilis, Bacteroides and Peptococcus isolated from infections in the field of obstetrics and gynecology.<BR>2. The T-1982 concentration in the retroperitoneal space exudate reached a peak value of 19.6μg/ml at 2 hours after the completion of 1g/60 minutes dripping infusion and decreased at a constant rate.<BR>3. We administered T-1982 at 2 g per day for a period of 7-9 days to 3 patients with gynecological infectious diseases. All cases proved to respond effectively. No side effects and abnormal laboratory findings were observed.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 36 (5), 1025-1032, 1983
Japan Antibiotics Research Association
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Details 詳細情報について
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- CRID
- 1390282680467190912
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- NII Article ID
- 130004130423
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- NII Book ID
- AN00002626
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- COI
- 1:STN:280:DyaL2c%2FhtFaitQ%3D%3D
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- ISSN
- 21865477
- 03682781
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- NDL BIB ID
- 2630634
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- PubMed
- 6620553
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed