CONCENTRATION OF DIBEKACIN SULFATE IN BONE

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  • KIKUCHI SHIN-ICHI
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center, Tokyo, Japan
  • HOSHIKA ICHIRO
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center, Tokyo, Japan
  • MATSUI TATSUYA
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center, Tokyo, Japan
  • HASUE MITSUO
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center, Tokyo, Japan

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Other Title
  • Dibekacin Sulfateの骨組織への移行の検討
  • Dibekacin Sulfate ノ ホネ ソシキ エ ノ イコウ ノ ケン

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Abstract

The concentrations inserum, cancellous and cortical bones of dibekacin sulfate were measured in 16 cases.Dibekacin sulfate rapidly penetrates into bone.The peak concentration in serum and cancellous bone is reached within 1 hour after intramuscular injection and the concentration in cancellous bone parallels that in serum. The concentration in cortical bone increases with time.Cancellous bone has higher concentration than cortical bone.Dibekacin sulfate is suitable for prevention of infection in orthopaedic surgery, because it maintains a bactericidal level in bone for enough time.

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