BODY FLUID CONCENTRATIONS OF CEPHALOSPORIN C DERIVATIVES BY INJECTABLE ADMINISTRATION

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  • SEIGA KANJI
    Department of Obstetrics and Gynecology, Kobe Social Insurance Central Hospital
  • YAMAJI KUNIHIKO
    Kinki Infection Disoese Center for Mothers and Children
  • SUGIYAMA YOKO
    Kinki Infection Disoese Center for Mothers and Children

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  • Cephalosporin C 誘導体注射投与における体内濃度
  • CephalosporinC ユウドウタイ チュウシャ トウヨ ニ オケル タイナイ ノウド

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Abstract

Body fluid concentrations of cephalosporin antibiotics are influenced by factors of route of administration, dosage, assay method, degree of protein binding, degree of renal clearance, metabolism in the body, etc. Blood and urine concentrations of cephalothin, cephaloridine and cefazolin were determined in adult volunteers by injectable administration to find out the correlationship of the above factors, and the following results were obtained:<BR>1. A remarkable dose-response relationship was observed in blood levels of cephalothin, cephaloridine and cefazolin by single injection of the dose of 0.25g-1.0g.<BR>2. The changing pattern of blood levels of three antibiotics showed a similar pattern on intramuscular and intravenous (one shot and drip) injection.<BR>3. A remarkable difference of assay values of cephalothin and cefazolin was observed when the blood samples were diluted with phosphate buffer or serum.<BR>4. A peculiar difference of the blood level and urinary excretion correlationship was observed between the three antibiotics of cephalosporin derivatives.<BR>5. No tendency of accumulation of the antibiotics in the blood was observed when usual clinical doses were administered to volunteers with normal renal function.<BR>6. The above-mentioned results seem to indicate an important role of serum-protein binding of the antibiotics. This problem will be elucidated in future.

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