A COMPARATIVE STUDY ON THE OTOTOXICITY OF DIBEKACIN AND TOBRAMYCIN ADMINISTERED BY INTRAVENOUS INFUSION
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- OHTANI IWAO
- Department of Otorhinolaryngology, Fukushima Medical College
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- OHTSUKI KOHSEI
- Department of Otorhinolaryngology, Fukushima Medical College
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- AIKAWA TOHRU
- Department of Otorhinolaryngology, Fukushima Medical College
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- OUCHI JIN
- Department of Otorhinolaryngology, Fukushima Medical College
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- NAKAYOSHI TAKEMI
- Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd.
Bibliographic Information
- Other Title
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- Comparative Study on the Ototoxicity of
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Description
Dibekacin(DKB)was the first antibiotic to be chemically synthesized on the basis of atheory concerning the inactivating mechanism clarified by UMEZAWAet al. 1, 2) Its chemical structural formula is as illustrated in Fig. 1. It is known that it has a potent antibacterial effect against both Gram-negative bacteria and Gram-positive bacteria, in particular against Pseudomonas aeruginosaand those bacteria resistant to many antibiotics, including gentamicin (GM). 3, 4)<BR>It has already been reported that the ototoxicity of DKB is less than that of GM. 5-7) It has also been reported that its ototoxicity is less than that of sisomicin or tobramycin (TOB). 8) However, these reports were based on results from intramuscular administrations, and hardly any reports have so far been published on the ototoxicity of various antibiotics in this group administered intravenously, possibly because of difficulties in experimental technique.<BR>In order to reproduce the effects of intravenous administration which is one of the methods of dosages for humans, we made a comparative study of the ototoxicity of DKB and TOB using rabbits to which continuous intravenous injections can usually be made with ease. The results obtained are described below.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 32 (10), 990-997, 1979
Japan Antibiotics Research Association
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Details 詳細情報について
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- CRID
- 1390282680468668032
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- NII Article ID
- 130004393184
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- NII Book ID
- AN00002626
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- COI
- 1:CAS:528:DyaL3cXhtVCnsb4%3D
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- ISSN
- 21865477
- 03682781
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- NDL BIB ID
- 2202595
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed