ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF CLINICAL ISOLATES OF<I>PSEUDOMONAS CEPACIA</I>

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  • IGARI JUN
    Department of Clinical Pathology, Juntendo University, School of Medicine
  • KOSAKAI NOZOMU
    Department of Clinical Pathology, Juntendo University, School of Medicine
  • OGURI TOYOKO
    Clinical Laboratory, Juntendo University Hospital

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Other Title
  • <I>Pseudomonas cepacia</I>感染症の臨床細菌学的検討第1報
  • Pseudomonas cepacia感染症の臨床細菌学的検討-1-臨床材料由来P. cepaciaの年次別分離頻度と薬剤感受性
  • Pseudomonas cepacia カンセンショウ ノ リンショウ サイキ
  • 臨床材料由来<I>P. cepacia</I>の年次別分離頻度と薬剤感受性

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Description

The yearly changes of relative frequency of glucose-nonfermentative Gram-negative bacilli except for P. aeuuginosa isolatod from various clinical specimens over the past 5 years were studied. Acinetobacter anituatum was the most commonly encountered strain and P. maltophilia and P. putida wero also frequently encountered during 1974 through 1977. In 1978, P. cepacia became a significantly predominant strain, which was 44.6% of all noh6ermentative Gram-negative bacilli excluding P. aeruginosa isolated in Juntendo Hospital.<BR>Antimicrobial susceptibility patterns of 59-61 clinical isolates of P.cepacia in 1978 were studied by agar dilution method, standardized. by the Japan Society of Chemotherapy.<BR>Miloxacin and minocycline inhibited more than 95% of the strain by the concentration of 6.25μg/ml.<BR>Nalidixic acid and sulfamethoxazole were sensitive to approximately 52% and 75% of the strains respectively.<BR>The minimal inhibitory concentration of gentamigin, tobramycin, amikacin, kanamycin, apalcillin, piperacillin and pipemidic acid for most strains was more than 12.5μg/ml.<BR>More than 90% of the strains were highly resistant to ampicillin, carbenicillin, sulbenicillin, ticarcillin, cefhzolin, cefotiam, tetracycline, clindamycin and colistin.

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