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RAPID BACTERICIDAL ACTIVITIES OF CARBAPENEMS AGAINST <I>Pseudomonas aeruginosa</I> IN SIMULATING HUMAN PLASMA CONCENTRATIONS
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- ISHII CHIKA
- Biological Research Laboratories, Sankyo Co., Ltd.
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- KAKUTA MASAYO
- Biological Research Laboratories, Sankyo Co., Ltd.
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- ABE TOMOMI
- Biological Research Laboratories, Sankyo Co., Ltd.
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- FUKUOKA TAKASHI
- Biological Research Laboratories, Sankyo Co., Ltd.
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- INOUE MATSUHISA
- Department of Microbiology, Kitasato University School of Medicine
Bibliographic Information
- Other Title
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- ヒト血漿中濃度シミュレート下における緑膿菌に対するカルバペネムの短時間殺菌力
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Description
The rapid bactericidal activities of panipenem (PAPM), imipenem (IPM), and meropenem (MEPM) against Pseudomonas aeruginosa were investigated by using in vitro pharmacodynamic model simulating the human plasma concentrations after intravenous drip infusion at 500mg for 0.5 hours. Against P. aeruginosa PAO1, PAPM and IPM showed rapider reduction in viable cell counts than MEPM at 0.5 hours after exposure. All drugs showed more than 3 log10 reduction in viable cell counts at 2 hours after exposure and bacterial regrowth was not observed throughout 6 hours. The initial bactericidal activities of the drugs against 4 clinical isolates within 1 hour after exposure were also investigated by the same method. Against P. aeruginosa strain 12475, the 3 drugs showed similar initial bactericidal activity but PAPM and IPM showed stronger initial bactericidal activity than MEPM against the other strains as did against P. aeruginosa PAO1. The morphological change of a strain 12489, for which the i itial bactericidal activities were different largely, after 0.5 hours exposure to simulated drugconcentrations was investigated by scanning electron microscope. PAPM and IPM induced morphological changes in most of the cells and cell lysis and bulge formation. On the other hand, MEPM induced changes of the surface structure of cells and slightly elongated cells, but not cell lysis.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 55 (2), 187-195, 2002
Japan Antibiotics Research Association
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Details 詳細情報について
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- CRID
- 1390282680470811136
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- NII Article ID
- 130004395928
- 10008465516
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- NII Book ID
- AN00002626
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- COI
- 1:CAS:528:DC%2BD38Xkt1Wkt7k%3D
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- ISSN
- 21865477
- 03682781
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- PubMed
- 12071096
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed