TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

YOKOTA MASAYUKI, TAKEDA UETO, ODAKI MASUZO, SASAKI HITOSHI, NIIZATO TETSUTARO, KAWAOTO HARUO, WATANABE HIROSHI, ITOH TAKASHI, ISHIWATARI NOBUYOSHI, KOEDA TAKEMI

doi:10.11553/antibiotics1968b.37.1355

TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

DOI PubMed

YOKOTA MASAYUKI

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TAKEDA UETO

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
ODAKI MASUZO

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
SASAKI HITOSHI

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
NIIZATO TETSUTARO

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
KAWAOTO HARUO

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
WATANABE HIROSHI

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
ITOH TAKASHI

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
ISHIWATARI NOBUYOSHI

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
KOEDA TAKEMI

Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.

書誌事項

タイトル別名

CHRONIC TOXICITY IN RATS

この論文をさがす

CiNii Books

説明

Miocamycin (MOM) is a derivative of midecamycin (MDM), a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). Its chemical structure is shown in Fig. 1. It is reported that MOM has the most interesting antibacterial properties among the known macrolide antibiotics3, 4). It has been known that the maximum tolerable dosage level of MOM, non-crystalline solid, was 1, 000 mg/kg in male and female rats when it was orally administered once daily for 5 weeks at daily dosage levels of 1, 000, 2, 000 and 4, 000 mg/kg as previously reported5).<BR>The objective of this study was to examine toxicological effects in male and female rats after repeated oral administration of MOM, non-crystalline solid, for 26 weeks at daily dosage levels of 62. 5, 125, 250, 500 and 1, 000mg/kg.