Clinical examination of doripenem for infectious diseases in gynecological and associated fields

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  • 産婦人科及び関連領域感染症に対するDoripenemの臨床的検討
  • サンフジンカ オヨビ カンレン リョウイキ カンセンショウ ニ タイスル Doripenem ノ リンショウテキ ケントウ

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Abstract

We examined the efficacy of doripenem(DRPM), a carbapenem antimicrobial agent, against infectious diseases in gynecological and associated fields, as well as its safety. The following resultswere obtained:<BR>1) The subjects were 20 patients with infection in the absence of pregnancy and 4 patients with pregnancy/puerperal infection. Intravenous drip of DRPM at 0.25g×2/day was performed for 3 to 8 days. The total doses ranged from 1.5 to 4.0g.<BR>2) Concerning its clinical efficacy, a complete response was achieved in 4 (16.7%) of the 24 patients, and a partial response in 18 (75.0%). The response rate was 91.7% (22/24). In 6 patients who did not respond to the previous agent, the response rate was 100% (6/6).<BR>3) Concerning its clinical efficacy with respect to clinically isolated bacteria, a complete response was achieved in 3 (10.0%) of the 30 strains, and a partial response in 26 (86.7%). Bacteria disappeared in 29 (96.7%) of the 30 strains.<BR>4) There were no side effects nor abnormalities in the laboratory data related to this agent.<BR>These results suggest the usefulness of DRPM in the treatment of gynecological infectious diseases.

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