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- TASAKA YOSHIKAZU
- Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
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- SUMI MASARU
- Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
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- NIKI YOSHIHITO
- Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
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- SOEJIMA RINZO
- Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
書誌事項
- 公開日
- 1988
- 資源種別
- journal article
- DOI
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- 10.11553/antibiotics1968b.41.836
- 公開者
- 公益財団法人 日本感染症医薬品協会
この論文をさがす
説明
The ability of antibiotics to enter cells, especially phagocytic cells, may be an important factor affecting therapy for infections caused by organisms which survive and proliferate intracellularly. It is well known that macrolides and clindamycin have high intracellular penetration ability1-4). We studied the uptake of rokitamycin (RKM), a new oral macrolide, using rabbit alveolar macrophages and 2 other macrolides for comparison. Intracellular concentrations of erythromycin and josamycin were, respectively, approximately 20 and 40 times higher than extracellular concentrations when they were incubated at an initial extracellular concentration of 5 μg/ml (I/E=20.1±2.6, 40.8±7.4). In comparison to these 2 macrolides, the uptake of RKM was massive and very rapid. The cellular concentration of RKM was approximately 120 times higher than the extracellular concentration. Uptake of the 3 macrolides by rabbit alveolar macrophages at 4° was approximately 10% of that at 37°. This study demonstrated that RKM was rapidly and massively accumulated by alveolar macrophages, and that the drug accumulation depends on temperature. These observations suggest that RKM therapy may be very effective for the treatment of some infectious diseases.
収録刊行物
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 41 (7), 836-840, 1988
公益財団法人 日本感染症医薬品協会
