Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2005)

GOTO HAJIME, TAKEDA HIDEKI, KAWAI SHIN, WATANABE SUGURU, OKAZAKI MITSUHIRO, SHIMADA KAORU, NAKANO KUNIO, YOKOUCHI HIROSHI, MORI TAKESHI, IGARI JUN, OGURI TOYOKO, YAMAMOTO MAKOTO, INOUE HIROSHI, NAKADATE TOSHIHIDE, SUWABE AKIRA, ASHINO YUGO, AOKI NOBUKI, HONMA YASUO, SUZUKI YASUTOSHI, KARASAWA YASUO, KUDO KOUICHIRO, KOBAYASHI NOBUYUKI, TANAKA TSUKASA, YOSHIMURA KUNIHIKO, KAWABATA MASAAKI, NAKAMORI YOSHITAKA, SUMITOMO MIDORI, OKA MIKIO, KOBASHI YOSHIHIRO, KOHNO SHIGERU, HIRAKATA YOICHI, KONDOU AKIRA, MATSUDA JUNICHI, NAKANO MICHIKO, OIKAWA SATORU

doi:10.11553/antibiotics1968b.61.209

From October 2005 to September 2006, we collected the specimen from 366 patients with lower respiratory tract infections in 12 institutions in Japan, and investigated the susceptibilities of isolated bacteria to various antibacterial agents and patients' characteristics. Of 411 strains that were isolated from specimen (mainly from sputum) and assumed to be bacteria causing in infection, 406strains were examined. The isolated bacteria were: Staphylococcus aureus 70, Streptococcus pneumoniae 85, Haemophilus influenzae 78, Pseudomonas aeruginosa (non-mucoid) 46, P aeruginosa (mucoid) 14, Klebsiella pneumoniae 21, and Moraxella subgenus Branhamella catarrhalis 40.<BR>Of 70 S. aureus strains, those with 2 yg/ml or less of MIC of oxacillin (methicillin-susceptible S.aureus: MSSA) and those with 4 μg/ml or more of MIC of oxacillin (methicillin-resistant S. aureus: MRSA) were 38 (54.3%) and 32 (45.7%) strains, respectively. Against MSSA, imipenem had the most potent antibacterial activity and inhibited the growth of 37 strains (97.4%) at 0.063 μg/ml or less. Against MRSA, arbekacin and vancomycin showed the most potent activity and inhibited the growth of all the strains at 1 Jug/ml. Carbapenems showed the most potent activities against S. pneumoniae and in particular, panipenem inhibited the growth of all the strains at 0.063 μg/ml or less. Faropenem also had a preferable activity and inhibited the growth of all the strains at 0.25 μg/ml. In contrast, there were high-resistant strains (MIC: over 128 μg/ml) for erythromycin (38.1%) and clindamycin (22.6%). Against H.influenzae, levofloxacin showed the most potent activity and its MIC₉₀ was 0.063 μg/ml or less.Meropenem showed the most potent activity against P aeruginosa (mucoid) and its MIC₉₀ was 0.5 μg/ml.Against P aeruginosa (non-mucoid), arbekacin had the most potent activity and its MIC₉₀ was 8 μg/ml. Against K pneumoniae, cefozopran was the most potent activity and inhibited the growth of all the strains at 0.063 μg/ml or less. Also, all the antibacterial agents except ampicillin generally showed a potent activity against M.(B.) catarrhalis and the MIC₉₀ of them were 2 μg/ml or less.<BR>The approximately half the number (53.6%) of the patients with respiratory infection were aged 70 years or older. Bacterial pneumonia and chronic bronchitis accounted for 44.3% and 29.8% of all the respiratory infection, respectively. The bacteria frequently isolated from the patients with bacterial pneumonia were S. aureus (15.4%), S. pneumoniae (23.4%), and H. influenzae (21.3%). S. aureus (25.4%) and S.pneumoniae (18.0%) also were frequently isolated from the patients with chronic bronchitis. Before the drug administration, the bacteria frequently isolated from the patients were S. pneumoniae (22.0%) and H. influenzae (21.4%). The bacteria frequently isolated from the patients treated with macrolides were S.pneumoniae and P aeruginosa, and their isolation frequencies were each 35.3%.

Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2005)

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