Double-Blind Trial of 3, 4-dideoxykanamycin B in the Treatment of Acute Supprative Otitis Media and Acute Tonsillitis

DOI
  • SANBE Buemon
    Debartment of Otorhinolaryngology. Kanto Teishin Hospital, Tokyo. Japan.
  • MURAKAMI Haruko
    Debartment of Otorhinolaryngology. Kanto Teishin Hospital, Tokyo. Japan.
  • AWATAGUCHI Shogo
    Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
  • SAITO Hisaki
    Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
  • KAMADA Shigeteru
    Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
  • KAWAMOTO Kazutomo
    Department of Otorhinolaryngology. Tohoku University School of Medicine. Sendai. Japan.
  • HORI Katsutaka
    Department of Otorhinolaryngology. Tohoku University School of Medicine. Sendai. Japan.
  • KAWAMURA Shozo
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
  • ICHIKAWA Ginichiro
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
  • SUGITA Rinya
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
  • YAMASHITA Koichi
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
  • SHIBUI Koichi
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
  • OGAWA Akira
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
  • OGURA Shuji
    Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
  • KOBAYASHI Yasuo
    Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
  • MASUKO Saburo
    Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
  • HOSUI Masafumi
    Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan.
  • BONO Kenji
    Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan.
  • BABA Shunkichi
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • HONDO Jun
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • WADA Kenji
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • HATANO Tsutomu
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • SEKIYA Tadao
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • OTSUKA Motoi
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • MIYAGAWA Kobun
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • SUZUKI Shigeru
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • YAMAMOTO Kaoru
    Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
  • SUGIYAMA Masao
    Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
  • YAMAZAKI Taro
    Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
  • HIROTO Ikuichiro
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
  • HAYASHIDA Kunihiko
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
  • YAMADA Atsunobu
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
  • SATO Kiichi
    Department of Pathology, lnstitute for the Deaf, Tokyo Medical and Dental University, Tokyo, Japan.

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Other Title
  • 急性中耳炎ならびに急性扁桃炎に対する3, 4-dideoxykanamycin Bの二重盲検試験による薬効評価

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Abstract

3, 4-dideoxykanamycin B is a new semisynthetic aminoglycosidic antibiotic derivated from Kanamycin B. Results of the fundamental studies on this drug reported that antimicrobial activity against Pseudomonas aeruginosa is more excellent than the other aminoglycosidic antibiotics. This paper describes the clinical results of comparative double-blind test on 3, 4-dideoxykanamycin B (DKB) and Gentamicin sulfate (GM) in the treatment of acute supprative otitis media and acute tonsillitis.<BR>Satisfactory results were obtained in 48 patients of 65 in the DKB group (73.9%) and in 41 patients of 63 in the GM group (65.1%). Statistical analysis of the obtained results revealed that there was no significant difference between the two groups. Generally, the most noteworthy side effect of aminoglycosidic antibiotics is ototoxity. Therefore, the patients in this study were observed with special attention to this point. But no disturbance of inner ear was noted in the DKB group. From the above results, 3, 4-dideoxykanamycin B (DKB) can be an effective antibiotic comparative to Gentamicin.

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