Double-Blind Trial of 3, 4-dideoxykanamycin B in the Treatment of Acute Supprative Otitis Media and Acute Tonsillitis
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- SANBE Buemon
- Debartment of Otorhinolaryngology. Kanto Teishin Hospital, Tokyo. Japan.
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- MURAKAMI Haruko
- Debartment of Otorhinolaryngology. Kanto Teishin Hospital, Tokyo. Japan.
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- AWATAGUCHI Shogo
- Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
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- SAITO Hisaki
- Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
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- KAMADA Shigeteru
- Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
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- KAWAMOTO Kazutomo
- Department of Otorhinolaryngology. Tohoku University School of Medicine. Sendai. Japan.
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- HORI Katsutaka
- Department of Otorhinolaryngology. Tohoku University School of Medicine. Sendai. Japan.
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- KAWAMURA Shozo
- Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
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- ICHIKAWA Ginichiro
- Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
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- SUGITA Rinya
- Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
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- YAMASHITA Koichi
- Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
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- SHIBUI Koichi
- Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
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- OGAWA Akira
- Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
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- OGURA Shuji
- Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
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- KOBAYASHI Yasuo
- Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
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- MASUKO Saburo
- Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
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- HOSUI Masafumi
- Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan.
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- BONO Kenji
- Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan.
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- BABA Shunkichi
- Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
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- HONDO Jun
- Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
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- WADA Kenji
- Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
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- HATANO Tsutomu
- Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
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- SEKIYA Tadao
- Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
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- OTSUKA Motoi
- Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
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- MIYAGAWA Kobun
- Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
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- SUZUKI Shigeru
- Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
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- YAMAMOTO Kaoru
- Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
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- SUGIYAMA Masao
- Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
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- YAMAZAKI Taro
- Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
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- HIROTO Ikuichiro
- Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
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- HAYASHIDA Kunihiko
- Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
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- YAMADA Atsunobu
- Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
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- SATO Kiichi
- Department of Pathology, lnstitute for the Deaf, Tokyo Medical and Dental University, Tokyo, Japan.
Bibliographic Information
- Other Title
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- 急性中耳炎ならびに急性扁桃炎に対する3, 4-dideoxykanamycin Bの二重盲検試験による薬効評価
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Abstract
3, 4-dideoxykanamycin B is a new semisynthetic aminoglycosidic antibiotic derivated from Kanamycin B. Results of the fundamental studies on this drug reported that antimicrobial activity against Pseudomonas aeruginosa is more excellent than the other aminoglycosidic antibiotics. This paper describes the clinical results of comparative double-blind test on 3, 4-dideoxykanamycin B (DKB) and Gentamicin sulfate (GM) in the treatment of acute supprative otitis media and acute tonsillitis.<BR>Satisfactory results were obtained in 48 patients of 65 in the DKB group (73.9%) and in 41 patients of 63 in the GM group (65.1%). Statistical analysis of the obtained results revealed that there was no significant difference between the two groups. Generally, the most noteworthy side effect of aminoglycosidic antibiotics is ototoxity. Therefore, the patients in this study were observed with special attention to this point. But no disturbance of inner ear was noted in the DKB group. From the above results, 3, 4-dideoxykanamycin B (DKB) can be an effective antibiotic comparative to Gentamicin.
Journal
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- OTOLOGIA FUKUOKA
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OTOLOGIA FUKUOKA 20 (3), 446-455, 1974
JIBI TO RINSHO KAI
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Details 詳細情報について
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- CRID
- 1390282680472020224
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- NII Article ID
- 130004402007
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- ISSN
- 04477227
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed