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STUDY OF THE USEFULNESS OF A KIT CONTAINING IMIPENEM/CILASTATIN POWDER WITH DILUENT FOR INJECTION
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- HIRAYAMA TAKESHI
- Department of Pharmacy, Kitasato University East Hospital
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- KUROYAMA MASAKAZU
- Department of Pharmacy, Kitasato University East Hospital
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- SHIMADA SHIGEHIKO
- Department of Pharmacy, Kitasato University Hospital School of Pharmacy, Kitasato University
Bibliographic Information
- Other Title
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- カルバペネム系抗生物質 (イミペネム/シラスタチン) のキット製品の有用性に関する実験的研究
- ACCURACY OF RECONSTITUTION
- 第2報調製精度の検討
Description
The usefulness of a kit consisting of non-glass packaging was evaluated in terms of accuracy of reconstitution. The newly developed imipenem/cilastatin powder-and-diluent kit consists of a polyolefin bag with two chambers that contain imipenem/cilastatin powder and diluent (0.9% saline, 100 ml), respectively.<BR>The accuracy of reconstitution was determined by nurses and pharmacists at the Kitasato University East Hospital by measuring the amount of materials remaining in vials after reconstitution using the syringe dilution method and the transfer-needle dilution method.<BR>The mean percent amounts of imipenem and cilastatin remaining after preparation by the syringe dilution method were 5.58±2.60% and 4.08±1.77%, respectively. The mean percent amounts of imipenem and cilastatin remaining after preparation by the transfer-needle dilution method were 3.99±2.28% and 3.71±2.09%, respectively. The amount of imipenem/cilastatin remaining in the newly developed kit should be negligible, because the kit serves as both a vial and a dosing package.<BR>Therefore, greater accuracy in terms of reconstitution is expected with the newly developed kit than with the traditional syringe dilution or transfer-needle dilution methods.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 49 (2), 211-217, 1996
Japan Antibiotics Research Association
