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- HOSODA TEIZO
- Department of Pediatrics, School of Medicine, Tokushima University
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- MASUDA MASAHIDE
- Department of Pediatrics, School of Medicine, Tokushima University
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- MIYAO MASUHIDE
- Department of Pediatrics, School of Medicine, Tokushima University
Bibliographic Information
- Other Title
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- 小児科領域におけるCefuzonamの使用経験
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Description
Clinical studies were performed on cefuzonam (L-105, CZON), a new cephem antibiotic, as follows.<BR>1. Cerebrospinal fluid (CSF) and serum concentrations.<BR>CSF and serum concentrations of CZON were measured in 1 case of septic arthritis without meningitis. One hour after 50 mg/kg intravenous bolus injection, the CSF and serum concentrations were 0.10 and 18.1 μg/ml, respectively, and CSF to serum concentration ratio was 0.55%.<BR>2. Clinical efficacy<BR>CZON was administrated to 15 patients in doses ranging 54.5-212.4 mg/kg/day (94.1 mg/kg/day on average) t.i.d. or q.i.d. for 4-12 days (6.5 days on average). Of those patients, 9 were with pneumonia, one each was with bronchitis, with tonsillitis, with septic arthritis, with septicemia, with purulent meningitis and with urinary tract infection.<BR>The overall efficacy rate was 100%, i.e., efficacy was excellent in 12, good in 3.<BR>Bacteriological efficacy was excellent, i.e., 8 of 8 strains were eradicated.<BR>Side effects were observed in 2 cases, i.e., one case with loose stool and another with eruption. Laboratory abnormalities to the drug were not observed during the treatment.<BR>The above results suggested that CZON would be a useful antibiotic for treating pediatric bacterial infections.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 40 (2), 449-459, 1987
Japan Antibiotics Research Association
