CLINICAL EFFICACY OF CEFPIROME SULFATE AGAINST Bacteroides SPECIES, Prevotella SPECIES AND Porphyromonas SPECIES

DOI 1 Citations 13 References
  • MIKAMO HIROSHIGE
    Department of Obstetrics and Gynecology, Gigu University School of Medicine
  • SATO YASUMASA
    Department of Obstetrics and Gynecology, Gigu University School of Medicine
  • HAYASAKI YOH
    Department of Obstetrics and Gynecology, Gigu University School of Medicine
  • 尹 香花
    岐阜大学医学部産科婦人科
  • TAMAYA TERUHIKO
    Department of Obstetrics and Gynecology, Gigu University School of Medicine
  • KAWAZOE KYOKO
    Department of Obstetrics and Gynecology, Ibi General Hospital
  • FURUTA NORIO
    Department of Obstetrics and Gynecology, Ibi General Hospital
  • IWASA SHINICHI
    Iwasa Maternity Hospital
  • ITO MITSUAKI
    Department of Obstetrics and Gynecology, Ogaki Municipal Hospital
  • NOMURA MASAO
    Department of Obstetrics and Gynecology, Ogaki Municipal Hospital
  • TSUKAHARA YOJIRO
    Department of Obstetrics and Gynecology, Ogaki Municipal Hospital
  • FURUI KENJI
    Department of Obstetrics and Gynecology, Ogaki Municipal Hospital
  • SAKAKIBARA KATSUMI
    Department of Obstetrics and Gynecology, Ogaki Municipal Hospital
  • HATTORI SENEI
    Department of Obstetrics and Gynecology, Ogaki Municipal Hospital
  • SUGIYAMA MICHIYO
    Department of Obstetrics and Gynecology, Gifu Prefectural Gifu Hospital
  • OHNISHI NAOMI
    Department of Obstetrics and Gynecology, Gifu Prefectural Gifu Hospital
  • HIROSE REIKO
    Department of Obstetrics and Gynecology, Gifu Prefectural Gifu Hospital
  • NAKAGAWA MIKI
    Department of Obstetrics and Gynecology, Gifu Prefectural Gifu Hospital
  • YAMADA YOSHITAKA
    Department of Obstetrics and Gynecology, Gifu Prefectural Gifu Hospital
  • IZUMI KOJI
    Department of Obstetrics and Gynecology, Gihoku General Hospital
  • MORISHITA SHIGEO
    Department of Obstetrics and Gynecology, Takayama Red Cross Hospital
  • WAKITA KATSUJI
    Department of Obstetrics and Gynecology, Takayama Red Cross Hospital
  • ITO TSUNEO
    Department of Obstetrics and Gynecology, Chuno General Hospital
  • HORIBE SHINJI
    Department of Obstetrics and Gynecology, Chuno General Hospital
  • IIDA KOJI
    Department of Obstetrics and Gynecology, Chuno General Hospital
  • OHTA TOSHIHARU
    Department of Obstetrics and Gynecology, Chuno General Hospital
  • SHINOHARA ARIYOSHI
    Department of Obstetrics and Gynecology, Tokai Central Hospital
  • HORI MASASHI
    Department of Obstetrics and Gynecology, Tokai Central Hospital
  • KONDOH HIDEAKI
    Department of Obstetrics and Gynecology, Tokai Central Hospital
  • KUMADA TOSHIO
    Department of Obstetrics and Gynecology, Tokai Central Hospital
  • MURATA SHUGO
    Department of Obstetrics and Gynecology, Tokai Central Hospital
  • HASHIYAMA TOSHIKO
    Department of Obstetrics and Gynecology, Hashima Municipal Hospital
  • ARAHORI KENJI
    Department of Obstetrics and Gynecology, Hashima Municipal Hospital
  • SHIRAKI SHINICHIRO
    Department of Obstetrics and Gynecology, Hirano General Hospital
  • TAKAGI HIROSHI
    Department of Obstetrics and Gynecology, Matsunami General Hospital
  • MATSUNAMI KAZUTOSHI
    Department of Obstetrics and Gynecology, Matsunami General Hospital
  • BABA YOSHITAKA
    Department of Obstetrics and Glynecology, Mino Prefectural Mino Hospital
  • WATANABE KUNITOMO
    Institute of Anaerobic Bacteriology, Gifu University School of Medicine

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Other Title
  • Bacteroides属, Prevotella属, Porphyromonas属に対する硫酸セフピロムの効果

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The injectable cephalosporin cefpirome(CPR)was launched in Japan in 1993. It has widely been used in the various infectious diseases. We therefore studied the clinical and bacteriological efficacy of CPR against infections caused by Bacteroides species, Prevotella species and Porphyromonas species frequently isolated from the obstetric and gynecologic infections. Thirteen institutions were involved in this study which ran from March 1994 to January 1999. The administration dosage of CPR was 2 to 4 gram per day administered by drip infusion or intravenous infusion. The duration of treatment was from 3 to 15days. The evaluations were performed before and after the treatment. CPR was administered to 194 patients with obstetric and gynecologic infections, and 146 of 194 cases were acceptable for the evaluation of drug efficacy.<BR>Bacteroides species were identified in 102 patients. Clinical efficacy in 146 cases was excellent in 12 patients, good in 110, fair in 9 and poor in 15 patients. The eradication rate for Bacteroides species could be in 37 cases out of 54 evaluable cases; Prevotella species in 38 out of 49; and Porphyromonas species in 5 out of 5. The overall assessment of bacteriological efficacy was “eradicated” in 91 cases out of 133(68.4%).<BR>Adverse reactions including abnormal findings in laboratory tests were seen in 8 patients(4.76%).<BR>Based on these results, CPR promises efficacy and safety in the treatment of obstetric and gynecologic infections due to Bacteroides species.

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