A CLINICOBACTERIOLOGIC STUDY ON CLAVULANIC ACID/AMOXICILLIN IN PEDIATRIC SINUSITIS

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  • 小児副鼻腔炎からの耐性肺炎球菌検出状況とclavulanic acid/amoxicillin投与症例の検討

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Abstract

We carried out clinical and bacteriological studies on clavulanic acid/amoxicillin and amoxicilln in pediatricsinusitis at 11 general practice settings. The results are summarized as follows.<BR>1. The major isolated organisms from content of middle meatus were Streptococcus pneumoniae 32.2%, Haemophilus influenzae 32.0% and Moraxella subgenus Branhamella catarrhalis 25.1%. Similar results wereobserved for the major isolates from nasopharynx.<BR>2. 62.1% of S. pneumoniae isolated were drug resistant S. pneumoniae (PISP, PRSP) and they wereincreasing year by year.<BR>3. Drug resistant S. pneumoniae was isolated from 38.6% of all cases.<BR>4. Regarding MIC90, CVA/AMPC showed superior antimicrobial activity against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis.<BR>5. The clinical efficacy, bacteriological efficacy and utility of CVA/AMPC-treated group were 78%, 58%and 72.8%, respectively, and they were significantly superior to AMPC-treated group.<BR>6. Adverse reactions were observed in 11.2% of CVA/AMPC group, involving diarrhea and stool loose and there was no statistical deference from those of AMPC group.

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