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- HARA TOHRU
- Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University
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- SAEKI HIDEAKI
- Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University
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- YAMAMOTO AKIRA
- Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University
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- OHTA KATSUYA
- Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University
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- SUZUKI TAKAHARU
- Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University
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- ARA MICHITO
- Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University
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- SUGAWARA MITSUO
- Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University
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- SANO YUTAKA
- Department of Plastic and Reconstructive Surgery, Tokyo Labor Accident Hospital
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- SAKUMA HIDEO
- Department of Plastic and Reconstructive Surgery, Yamagata Prefectural Central Hospital
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- SATOH KIMIKO
- Department of Plastic and Reconstructive Surgery, Yamagata Prefectural Central Hospital
Bibliographic Information
- Other Title
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- 形成外科領域におけるセフロキシムの皮膚移行性の検討
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Description
Concentrations of cefuroxime (CXM) in the skin and the serum of 24 patients were examined. CXM (0.75g, 1.5g) was administered to these patients intravenously in one shot.<BR>The skin and the serum were collected at 30 and 60 minutes after the injection. Concentrations of CXM in the skin were following:<BR>0.75g, 30min.; 11.4±5.3μg/g<BR>60min.; 9.5± 4.7μμg/g<BR>1.5g, 30min.; 17.1±6.8μg/g<BR>60min.; 15.7±13.2μg/g<BR>Concentration ratios (skin/serum) at 60 minutes after the injection were from 72.5% to 79.2%. The binding ratio of CXM to serum protein was 41%, which was lower than most other antibiotics.<BR>High concentration levels of CXM were maintained in the skin for a long time. Based on this study, we consider that CXM is effective in the skin surgery.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 41 (1), 10-17, 1988
Japan Antibiotics Research Association