CLINICAL EVALUATION OF CEFPODOXIME PROXETIL IN THE TREATMENT OF SKIN AND SOFT TISSUE INFECTIONSA DOUBLE BLIND COMPARISON OF CEFPODOXIME PROXETIL AND CEFACLOR
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- YURA JIRO
- The First Department of Surgery, School of Medicine, Nagoya City University
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- SHINAGAWA NAGAO
- The First Department of Surgery, School of Medicine, Nagoya City University
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- MIZUNO AKIRA
- The First Department of Surgery, School of Medicine, Nagoya City University
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- WATANABE SUSUMU
- The First Department of Surgery, School of Medicine, Nagoya City University
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- ANDO MASAHIDE
- The First Department of Surgery, School of Medicine, Nagoya City University
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- SAKAI KATSUJI
- The Second Department of Surgery, School of Medicine, Osaka City University
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- UEDA TAKAMI
- The Second Department of Surgery, School of Medicine, Osaka City University
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- MORIMOTO KEN
- The Second Department of Surgery, School of Medicine, Osaka City University
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- NAKAMURA TAKASHI
- Department of Surgery, Tenshi Hospital
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- HASHIMOTO IKUO
- Department of Surgery, Tenshi Hospital
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- SAWADA YASUO
- Department of Surgery, Tenshi Hospital
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- KUNII YASUO
- Department of Surgery, Sendai National Hospital
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- HIRAYAMA TAKASHI
- Department of Surgery, Sendai National Hospital
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- KATO SHIGETSUGU
- Department of Surgery, Tokyo Dental College
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- ONO SHIGEO
- Department of Surgery, Tokyo Dental College
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- SAKABE TAKASHI
- The Third Department of Surgery, School of Medicine, Nihon University
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- IWAI SHIGETOMI
- The Third Department of Surgery, School of Medicine, Nihon University
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- TAJIMA KAYO
- The Third Department of Surgery, School of Medicine, Nihon University
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- KUNIMATSU MASAHIKO
- The Third Department of Surgery, School of Medicine, Nihon University
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- ANRAKU TSUTOMU
- Department of Surgery, Nittsu Hospital
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- ISHIBIKI KYUYA
- Department of Surgery, School of Medicine, Keio University
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- AIKAWA NAOKI
- Department of Surgery, School of Medicine, Keio University
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- TSUBOUCHI TAIJIRO
- Department of Surgery, School of Medicine, Keio University
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- SAITO TOSHIAKI
- Department of Surgery, Kawasaki Municipal Hospital
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- NAKATSU TAKAYOSHI
- Department of Surgery, Kawasaki Municipal Hospital
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- ARAI TATEYUKI
- Department of Surgery, Kawasaki Municipal Hospital
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- YOKOYAMA ISAO
- Department of Surgery, Kawasaki Municipal Hospital
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- TSUYUKI KEN
- Department of Surgery, Kawasaki Municipal Hospital
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- YOSHIMI OSAMU
- Department of Surgery, Tokai Teishin Hospital
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- ISHIKAWA SHU
- Department of Surgery, Tokai Teishin Hospital
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- TANABE KATSUHIKO
- Department of Surgery, Rinko Hospital
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- HAYAKAWA YOSHIAKI
- Department of Surgery, Rinko Hospital
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- KIMURA SHOJI
- Department of Surgery, Kohseiren Bisai Hospital
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- SUZUKI ICHIYA
- Department of Surgery, Kohseiren Bisai Hospital
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- TACHI YOSHIMASA
- Department of Surgery, Nagoya-shi Koseiin Geriatric Hospital
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- FUKUHARA ASAKATSU
- Department of Surgery, Kohseiren Asuke Hospital
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- YAMANAKA YUJI
- Department of Surgery, Kohseiren Asuke Hospital
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- USAMI SHIZUO
- Department of Surgery, Kariya General Hospital
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- OHKUBO KEN
- Department of Surgery, Kariya General Hospital
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- HASHIMOTO SHUN
- Department of Surgery, Takahama City Hospital
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- IWAI AKIHIKO
- Department of Surgery, Chita Kohsei Hospital
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- HAYAKAWA TETSUSHI
- Department of Surgery, Chita Kohsei Hospital
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- ITO TADAO
- Department of Surgery, Tajimi Municipal Hospital
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- ITO AKITOSHI
- Department of Surgery, Kakegawa City Hospital
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- EMINA MAKOTO
- Department of Surgery, Kakegawa City Hospital
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- OKADA HIDEYA
- Department of Surgery, Hamamatsu National Hospital
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- KANAMORI KAN
- Department of Surgery, Hamamatsu National Hospital
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- FUKUMOTO IKURO
- Department of Surgery, Morimachi General Hospital
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- SHIBATA YOSHITAKA
- Department of Surgery, Morimachi General Hospital
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- INUKAI AKIO
- Department of Surgery, Inabe Kohsei Hospital
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- MATSUGAKI KEIJI
- Department of Surgery, Inabe Kohsei Hospital
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- SAKAKIBARA OSAMU
- Department of Surgery, Komono Kohsei Hospital
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- SAKURAI SATOSHI
- Department of Surgery, Komono Kohsei Hospital
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- MURATA YUKITAKA
- Department of Surgery, Yasu Hospital
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- ISHIKAWA MASAKAZU
- Department of Surgery, Yasu Hospital
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- HIRATA SANAE
- Department of Surgery, Osaka City Shirokita Hospital
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- FUJIMOTO MIKIO
- Department of Surgery, Fujiidera City Hospital
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- OHNO KOUICHI
- Department of Surgery, Fujiidera City Hospital
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- SASAKI TAKEYA
- Department of Surgery, Fujiidera City Hospital
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- MORIMOTO YUZURU
- Department of Surgery, Morimoto Hospital
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- YOKOYAMA TAKASHI
- The First Department of Surgery, School of Medicine, Hiroshima University
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- KODAMA TAKASHI
- The First Department of Surgery, School of Medicine, Hiroshima University
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- MIYOSHI NOBUKAZU
- Department of Surgery, Kure Kyosai Hospital
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- KISHI AKIHIRO
- Department of Surgery, Kake Town Hospital
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- SHIMURA HIDEHIKO
- The First Department of Surgery, School of Medicine, Fukuoka University
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- YAMAMOTO HIROSHI
- The First Department of Surgery, School of Medicine, Fukuoka University
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- NAKASHIMA MITSUYOSHI
- Department of Pharmacology, Hamamatsu Medical College
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- KONO MEGUMI
- Department of Microbiology, Tokyo College of Pharmacy
Bibliographic Information
- Other Title
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- 皮膚軟部組織感染症に対するCefpodoxime proxetilの薬効評価Cefaclorとの二重盲検比較試験
Abstract
In order to objectively evaluate the effectiveness, safety and usefulness of the new oral cephem cefpodoxime proxetil (CS-807, CPDX-PR) for the treatment of skin and soft tissue infections, a double-blind comparative study was undertaken using cefaclor (CCL) as the control drug. CPDX-PR and CCL were administered for 7 days at daily doses of 400mg (divided into 2 portions) and 750mg (divided into 3 portions), respectively.<BR>A total of 243 patients (118 in the CPDX-PR group and 125 in the CCL group) was treated in this study. The effectiveness, safety and usefulness were evaluated in 222 (106 in the CPDX-PR group and 116 in the CCL group), 234 (113 in the CPDX-PR group and 121 in the CCL group) and in 223 patients (107 in the CPDX-PR group and 116 in the CCL group), respectively. There were no differences in patients' backgrounds between the 2 groups, except for the presence on the absence of surgical treatments.<BR>The results we obtained are summarized below:<BR>1. In the evaluation of clinical efficacy by the subcommittee, excellent, good, fair and poor efficacy were observed in 36, 43, 17 and 10 patients in the CPDX-PR group, respectively; the efficacy rate was, therefore, calculated to be 74.5%. As for the CCL group, respective results were observed in 50, 39, 17 and 10 patients, indicating an efficacy rate of 76.7%. There was no significant difference between the 2 groups. Improvement rates judged by physicians in charge were 80.2% in the CPDX-PR group and 88.8% in the CCL group. Moreover, no significant difference in diseases or severity were found between the 2 groups.<BR>2. As for the bacteriological efficacy, the 2 groups showed high elimination rates, as 90.1% and 91.6% of the disease causing bacteria were eliminated in the CPDX-PR group and in the CCL group, respectively. Elimination rates in single infections with Staphylococcus aureus were determined to be 85.7% in the CPDX-PR group and 85.0% in the CCL group.<BR>3. Although 6 patients in the CPDX-PR group and 2 patients in the CCL group developed side effects, which were mainly gastrointestinal symptoms, there was no significant difference in the incidence of side effects between the 2 groups. Abnormal laboratory values were found in 5 patients in the CPDX-PR group and 1 patient in the CCL group.<BR>4. There was no significant difference in the usefulness between the 2 groups.<BR>Based on these results, it was judged that CPDX-PR is useful for the treatment of skin and soft tissue infections, as CCL.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 41 (10), 1517-1537, 1988
Japan Antibiotics Research Association