COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1993)
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- KUMAMOTO YOSHIAKI
- Department of Urology, Sapporo Medical University, School of Medicine
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- HIROSE TAKAOKI
- Department of Urology, Sapporo Medical University, School of Medicine
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- TANAKA NORIAKI
- Department of Urology, Sapporo Medical University, School of Medicine
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- HIKICHI YOSHINAO
- Katta Polyclin ic Hospital
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- SHIGETA SHIRO
- Department of Bacteriology, Fukushima Medical College
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- SHIRAIWA YASUO
- Department of Urology, Fukushima M edical College
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- KAMEOK HIROSHI
- Department of Urology, Fukushima M edical College
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- YOSHIDA HIROSHI
- Department of Laboratory Medicine, Fukushim a Medical College
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- TAZAKI HIROSHI
- Department of Urology, School of Medicine, Keio University
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- IRI HISAMI
- Central Clinical Laboratories, School of Medicine, Keio University
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- UCHIDA HIROSHI
- Central Clinical Laboratories, School of Medicine, Keio University
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- KOBAYASHI YOSHIO
- Central Clinical Laboratories, School of Medicine, Keio University
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- MATSUDA SEIJI
- Department of Gyne cology, Koto Hospital
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- KITAGAWA RYUICHI
- Department of Urology, Juntendo University, School of M edicine
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- FUJIME MAKOTO
- Department of Urology, Juntendo University, School of M edicine
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- FUJITA KAZUHIKO
- Department of Urology, Juntendo University, School of M edicine
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- IGARI JUN
- Department of Clinical Pathology, Juntendo University, School of Medicine
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- OGURI TOYOKO
- Central Clinical Laboratories, Juntendo University
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- KOSAKAI NOZOMU
- Juntendo University Urayasu Hospital
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- YAMAGUCHI KEIZO
- Department of Microbiology, School of Medicine, Toho University
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- MOCHIDA CHIKAKO
- Department of Microbiology, School of Medicine, Toho University
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- FURUSAWA TARO
- Department of Urology, Kyoto Second Red Cross Hospital
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- TAKEUCHI YASUKO
- Central Clinical Laboratories, Kyoto Second Red Cross H ospital
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- MORIYAMA HIROMI
- Central Clinical Laboratories, Kyoto Second Red Cross H ospital
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- SHIBATA KIKUTARO
- Central Clinical Laboratories, Kyoto Second Red Cross H ospital
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- YONEZU SEIBUN
- The First Department of Internal M edicine, Kansai Medical University
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- TAKAHA MINATO
- Department of Urology, National O saka Hospital
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- MATSUMIYA KIYOMI
- Department of Urology, National O saka Hospital
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- TANAKA MICHIO
- Clinical Laboratories, N ational Osaka Hospital
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- KAKU MITSUO
- Department Laboratory, School of Medicine, Nagasaki University
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- SUGAWARA KAZUYUKI
- Department Laboratory, School of Medicine, Nagasaki University
Bibliographic Information
- Other Title
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- 尿路感染症分離菌に対する経口並びに注射用抗菌薬の抗菌力比較 (第15報1993年)
- I. SUSCEPTIBILITY DISTRIBUTION
- その1.感受性について
Abstract
The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 657 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1993 to May 1994. Of the above total bacterial isolates, Gram-positive bacteria accounted for 28.3% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 71.7% and most of them were Escherichia coll.<BR>1.Enterococcus faecalis<BR>Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2μg/ml. Piperacillin (PIPC) was also active with the MIC90 of 8μg/ml. The others were not so active with the MIC90s of 32μg/ml or above.<BR>2.Staphylococcus aureus including MRSA<BR>VCM showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 1μg/ml. Arbekacin (ABK) was also active with the MIC90 of 2μg/ml. The others were not so active with the MIC90s of 32μg/ml or above.<BR>3.Staphylococcus epidermidis<BR>VCM showed the strongest activity against S. epidermidis isolated from patients with urinary tract infections. Its MIC90 was 1μg/ml. ABK was also active with the MIC90 of 4μg/ml. The others except ABPC were not so active with the MIC90s of 32μg/ml or above.<BR>4.Streptococcus agalactiae<BR>Most of the agents were active against S. agalactiae isolated from patients with urinary tract infections. Penicillins, cephems, erythromycin (EM), and clindamycin (CLDM) showed the highest activities. The MIC90s of them were 0.25μg/ml or below. Amikacin (AMK) and minocycline (MINO) showed somewhat low activities with the MIC90s of 16μg/ml.<BR>5.Citrobacter freundii<BR>IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 2μg/ml. Cefozopran (CZOP) and gentamicin (GM) were also active with the MIC90s of 8μg/ml. Penicillins and cephems generally were not so active.<BR>6.Enterobacter cloacae<BR>IPM and GM sh owed the highest activities against E. cloacae. The MIC90s of them were 1μg/ml. CZOP and tosufloxacin (TFLX) were also active with the MIC90s of 8μg/ml. Penicillins and cephems except CZOP showed lower activities with the MIC90s of 64μg/ml or above.<BR>7.Escherichia coli<BR>Most of antimicrob ial agents were active against E. coli. Flomoxef (FMOX), CZOP, IPM, CPFX and TFLX showed the highest activities against E. coli. The MIC90s of them were 0.125μg/ml or below. Cefmenoxime (CMX), ceftazidime (CAZ), cefuzonam (CZON), latamoxef (LMOX), carumonam (CRMN), norfloxacin (NFLX) and ofloxacin (OFLX) were also active with the MIC90s of 0.25μg/ml. Penicillins and MINO were not so active with the MIC90s of 32μg/ml or above.<BR>8.Klebsiella pneumoniae<BR>CZOP, IPM a nd CRMN showed the highest activities against K. pneumoniae. The MIC90s of them were 0.125μg/ml or below. CAZ, CZON, CFIX, CPFX and TFLX were also active the MIC90s of 0.25μg/ml. Penicillins were not so active with the MIC90s of 128μg/ml or above.<BR>9.Proteus mirabilis<BR>P. mirabilis was susceptible to a majority of drugs. CMX, CAZ, CZON, LMOX, CFIX, CRMN and CPFX showed the highest activities against P. mirabilis isolated from patients with urinary tract infections. The MIC90s of them were 0.125μg/ml or below. MINO was not so active with the MIC90 of 256μg/ml or above.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 48 (11), 1757-1787, 1995
Japan Antibiotics Research Association